[Science Advances] Prof. Wei HANG & Prof. Jianfeng LI's groups published a paper entitled Tip-enhanced ablation and ionization mass spectrometry for nanoscale chemical analysis

Publish Date:2017-12-15     Visited921Times    bsp;  

Title: Tip-enhanced ablation and ionization mass spectrometry for nanoscale chemical analysis

Author: Zhisen Liang, Shudi Zhang, Xiaoping Li, Tongtong Wang, Yaping Huang, Wei Hang*, Zhilin Yang, Jianfeng Li* and Zhongqun Tian

Summary:

Spectroscopic methods with nanoscale lateral resolution are becoming essential in the fields of physics, chemistry, geology, biology, and materials science. However, the lateral resolution of laser-based mass spectrometry imaging (MSI) techniques has so far been limited to the microscale. This report presents the development of tip-enhanced ablation and ionization time-of-flight mass spectrometry (TEAI-TOFMS), using a shell-isolated apertureless silver tip. The TEAI-TOFMS results indicate the capability and reproducibility of the system for generating nanosized craters and for acquiring the corresponding mass spectral signals. Multi-elemental analysis of nine inorganic salt residues and MSI of a potassium salt residue pattern at a 50-nm lateral resolution were achieved. These results demonstrate the opportunity for the distribution of chemical compositions at the nanoscale to be visualized.






Full Link: http://advances.sciencemag.org/content/3/12/eaaq1059