化学生物学 Chemical Biology
Eric Meggers课题组: 化学生物学和药物化学

(Eric Meggers—Chemical biology and medicinal chemistry)

Group Members
Associate Professor Lei Gong (龚磊)

Selected Publications

  1. “Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors”, L. Feng, Y. Geisselbrecht, S. Blanck, A. Wilbuer, G. E. Atilla-Gokcumen, P. Filippakopoulos, K. Kr?ling, M. A. Celik, K. Harms, J. Maksimoska, R. Marmorstein, G. Frenking, S. Knapp, L.-O. Essen, E. Meggers*, J. Am. Chem. Soc. 2011, 133, 5976-5986.
  2. “From Conventional to Unusual Enzyme Inhibitor Scaffolds: The Ongoing Quest for Target Specificity”, E. Meggers*, Angew. Chem. Int. Ed. 2011, 50, 2442-2448.
  3. “Asymmetric Coordination Chemistry by Chiral-Auxiliary-Mediated Dynamic Resolution under Thermodynamic Control”, Z. Lin, L. Gong, M. A. Celik, K. Harms, G. Frenking, E. Meggers*, Chem. Asian J. 2011, 6, 474-481.
  4. “Isomerization-Induced Asymmetric Coordination Chemistry: From Auxiliary Control to Asymmetric Catalysis”, L. Gong, Z. Lin, K. Harms, E. Meggers*, Angew. Chem. Int. Ed. 2010, 49, 7955-7957.
  5. “Synthesis and Properties of the Simplified Nucleic Acid GNA”, E. Meggers*, L. Zhang, Acc. Chem. Res. 2010, 43, 1092-1102.
  6. “Chiral Salicyloxazolines as Auxiliaries for the Asymmetric Synthesis of Ruthenium Polypyridyl Complexes”, L. Gong, S. P. Mulcahy, D. Devarajan, K. Harms, G. Frenking, E. Meggers*, Inorg. Chem. 2010, 49, 7692-7699.
  7. “Iridium Complex with Antiangiogenic Properties”, A. Wilbuer, D. H. Vlecken, D. J. Schmitz, K. Kr?ling, K. Harms, C. P. Bagowski, E. Meggers*, Angew. Chem. Int. Ed. 2010, 49, 3839-3842.
  8. “Atomic Resolution Structure of the Simplified Nucleic Acid GNA”, M. K. Schlegel, L.-O. Essen, E. Meggers*, Chem. Commun. 2010, 46, 1094-1096.
  9. “Chiral Auxiliaries as Emerging Tools for the Asymmetric Synthesis of Octahedral Metal Complexes”, E. Meggers*, Chem. Eur. J. 2010, 16, 752-758.
  10. “From Imide to Lactam Metallo-pyridocarbazoles: Distinct Scaffolds for the Design of Selective Protein Kinase Inhibitors”, N. Pagano, E. Y. Wong, T. Breiding, H. Liu, A. Wilbuer, H. Bregman, Q. Shen, S. L. Diamond, E. Meggers*, J. Org. Chem. 2009, 74, 8997-9009.
  11. “Chiral-Auxiliary-Mediated Asymmetric Synthesis of Tris-Heteroleptic Ruthenium Polypyridyl Complexes”, L. Gong, S. P. Mulcahy, K. Harms, E. Meggers*, J. Am. Chem. Soc. 2009, 131, 9602-9603.
  12. “Targeting Metal Complexes to Proteins”, E. Meggers*, Chem. Commun. 2009, 1001-1010;
  13. “Insight into the High Duplex Stability of the Simplified Nucleic Acid GNA”, M. Schlegel, X. Xie, L. Zhang, E. Meggers*, Angew. Chem. Int. Ed. 2009, 48, 960-963.
  14. “Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes”, J. Maksimoska, L. Feng, K. Harms, C. Yi, J. Kissil, R. Marmorstein, E. Meggers*, J. Am. Chem. Soc. 2008, 130, 15764-15765.
  15. “Duplex Structure of a Minimal Nucleic Acid”, M. K. Schlegel, L. Essen, E. Meggers*, J. Am. Chem. Soc. 2008, 130,

Selected Topics of Current Interest
1.Chemical biology and medicinal chemistry with inert metal complexes

2.Asymmetric synthesis of metal complexes: From auxiliary mediation to asymmetric catalysis


Eric Meggers 教授、博士生导师

 
学士 (德国波恩大学,1995)
博士 (瑞士巴塞尔大学,1999)
博士后 (美国斯克里普斯研究所,1999-2002)

厦门大学中央“千人计划”第五批入选者
国家级特聘教授

主要社会兼职:
马尔堡德国化学会主席

电子邮箱:meggers@xmu.edu.cn

研究兴趣:金属配合物的化学生物学以及药物化学研究,八面体金属配合物的不对称合成方法学, 生物活性金属配合物的立体选择性合成。

 




Eric Meggers Professor

 
B. E. (1995), University of Bonn, Germany;
Ph. D. (1999), University of Basel, Switzerland;
Post-doc (1999-2002), The Scripps Research Institute, USA

Research Interests: Chemical biology and medicinal chemistry with inert metal complexes; Asymmetric synthesis of octahedral coordination complexes; Stereoselective synthesis of bioactive metal complexes

Honors and Awards:
Camille Dreyfus Teacher-Scholar Award (2006);
Alfred P. Sloan Research Fellowship (2006-2008);
Novartis Chemistry Lectureship Award (2009-2010);