生物化工 Biochemical Engineering
方柏山课题组: 生物催化与生物转化

Bai-shan FANG — Biocatalysis and Biotransformation

Group Members
Assistant Professor Shizhen Wang (王世珍)

Selected Publications

  1. “Discriminating acidic and alkaline enzymes using a random forest model with secondary structure amino acid composition”, G.-Y. Zhang, H.-C. Li , B.-S. Fang, PROCESS BIOCHEMISTRY, 2009, 44, 654-660.
  2. “BestCodon: Novel software for codon bias analysis”, J.-C. Yu, L. Shui, B.-S. Fang, JOURNAL OF BIOTECHNOLOGY, 2008, 136: 349-350.
  3. “Predicting the cofactors of oxidoreductases based on amino acid composition distribution and Chou's amphiphilic pseudo-amino acid composition”, G.-Y. Zhang, B.-S. Fang, JOURNAL OF THEORETICAL BIOLOGY, 2008, 253, 310-315.
  4. “Predicting Lipase Types by Improved Chou's Pseudo-Amino Acid Composition”, G.-Y. Zhang, H.-C. Li, J.-Q. Gao, B.-S. Fang, PROTEIN AND PEPTIDE LETTERS, 2008, 15, 1132-1137.
  5. “Structural identification of ginseng polysaccharides and testing of their antioxidant activities”, D.-H. Luo, B.-S. Fang, CARBOHYDRATE POLYMERS 2008, 72, 376–381,
  6. “Heterologous expression, purification, and characterization of xylose reductase from Candida shehatae”, X.-X. Wang, B.-S. Fang, J.-X. Luo, et al. BIOTECHNOL LETT 2007, 29: 1409-1412,.
  7. “Simultaneous HPLC determination of four key metabolites in the metabolic pathway for production of 1,3-propanediol from glycerol”, H.-W. Chen, B.-S. Fang, Z.-D. Hu, CHROMATOGRAPHIA 2007, 65: 629-632.
  8. “LogitBoost classifier for discriminating thermophilic and mesophilic proteins”, G.-Y. Zhang, B.-S. Fang, J BIOTECHNOL 2007,127: 417-424,
  9. “Support vector machine for discrimination of thermophilic and mesophilic proteins based on amino acid composition”, G.-Y. Zhang, B.-S. Fang, PROTEIN PEPTIDE LETT 2006,13: 965-970.
  10. “A uniform design-based back propagation neural network model for amino acid composition and optimal pH in G/11 xylanase”, G.-Y. Zhang, B.-S. Fang, J CHEM TECHNOL BIOT 2006, 81: 1185-1189.
  11. “The influence of dipeptide composition on optimum temperature of alcohol dehydrogenase”, G.-Y. Zhang, B.-S. Fang, ENZYME MICROB TECH 2006, 39: 811-816.
  12. “Application of amino acid distribution along the sequence for discriminating mesophilic and thermophilic proteins”, G.-Y. Zhang, B.-S. Fang, PROCESS BIOCHEM 2006, 41: 1792-1798.
  13. “Discrimination of thermophilic and mesophilic proteins via pattern recognition methods”, G.-Y. Zhang, B.-S. Fang, PROCESS BIOCHEM 2006, 41: 552-556.
  14. “Optimization of expression of dhaT gene encoding 1,3-propanediol oxidoreductase from Klebsiella pneumoniae in Escherichia coli using the methods of uniform design and regression analysis”, Y. Cao, Q.-R. Xia, B.-S. Fang, J CHEM TECHNOL BIOT 2006, 81: 109-112.
  15. “Optimization of process parameters for key enzymes accumulation of 1,3-propanediol pro uction from Klebsiella pneumoniae”, H.-W. Chen, B.-S. Fang, Z.-D. Hu, BIOCHEM ENG J 2005, 25: 47-53.
  16. “Optimization of polymerase chain reaction-amplified conditions using the uniform design method”, Y. Cao, Y.-Y.Zheng, B.-S. Fang, J CHEM TECHNOL BIOT 2004, 79: 910-913.
  17. “Cloning and sequence analysis of the dhaT gene of the 1,3-propanediol regulon from Klebsiella pneumoniae”, Y.-Y. Zheng, Y. Cao, B.-S. Fang, BIOTECHNOL LETT 2004, 26: 251-255.
  18. “Using genetic algorithms coupling neural networks in a study of xylitol production: medium optimization”, B.-S. Fang H.-W. Chen, X.-L. Xie, et al. PROCESS BIOCHEM 2003, 38: 979-985,.

Selected Targets of Current Interest


方柏山 教授、博士生导师

 
博士(天津大学)
访问(德国斯图加特大学生化工程研究所,1991-1993年;德国生物技术研究中心,2000-2001年)
学士(浙江大学)

中国微生物学会生化过程模型化与控制专业委员会副主任
2008年5月获得“福建省第四届高等学校教学名师奖”; 2004年9月获得“全国优秀教师”称号; 1998年9月获得“国务院侨办优秀教师”称号。

电话:(0592)2185869
传真:(0592)2184822
电子邮箱:fbs@xmu.edu.cn

研究兴趣:合成生物学;酶的挖掘与改造;生物分子机器构建;新型生物催化剂的应用。

 




Bai-shan FANG Chair Professors of "Minjiang Scholars Programme"

 
Ph. D., Tianjin University, China;
Visiting Scholar, University of Stuttgart, Germany (1991-1993); Biotechnology Research Center(GBF), Germany (2000 -2001) ;
B.S., Zhejiang University, China.

Research Interests: Synthetic biology;Mining and the transformation of the enzyme; Construction of bio-molecular machines; The application of new biocatalysts.

Honors and Awards:
2008, University Distinguished Teacher of Fujian Province;
2004, National Excellent Teachers;
1998, Excellent Teachers of Overseas Chinese Affairs Office of the State Council.