化学生物学 Chemical Biology
韩守法课题组: 生物信号响应分子与材料

Shou-Fa HAN — Bioresponsive Sensor for Cancer Imaging

Group Members

Associate Professor Yang Liu (杨 柳)

Selected Publications

  1. “Visual and fluorogenic detection of nerve agent stimulant via Lossen rearrangement of Rhodamine-hydroxamate;Chemcial Communication”, S.-F. Han*, Z.-W.Xue, Z. Wang and T.-B. Wen, 2010, 46, 8413-8415.
  2. “Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo. Duong, Bao Hoa; Tian, Hua; Completo, Gladys; S.-F. Han; Vela, Jose Luis; Ota, Miyo; Kubitz, Michael; Bovin, Nicolai; Paulson, James C.; Nemazee, David. Journal of Experimental Medicin”e,2010, 207, 445.
  3. “Multivalent mannose-displaying nanoparticles constructed from poly{styrene-co-[(maleic anhydride)-alt-styrene]}”R. Su, L. Li, X. Chen, J. Han, S.-F. Han*. Organic and Biomolecular Chemistry. 2009, 7, 2040.
  4. “Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates”, W. Fang, Y. Cai, X. Chen, R. Su, T. Chen, N. Xia, L. Li, Q. Yang, J.* Han, S.-F. Han. Bioorganic and Medicinal Chemistry Letter, 2009, 19:1903.
  5. “Sialoside analog arrays for rapid identification of high affinity siglec ligands”, Ola Blixt, S.-F. Han, L. Liao, Y. Zeng, J. Hoffmann, James C. Paulson; Journal of the American Chemical Society, 2008, 130, 6680–6681.
  6. “Bi-functional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells”, Mary O’Reilly, Brian E. Collins, S.-F. Han, L. Liao, Cory Rillahan, Pavel I. Kitov, David R. Bundle and James C. Paulson. Journal of the American Chemical Society, 2008, 130, 4578.
  7. “Synthesis of 9-substituted sialic acids as probes for CD22-ligand interactions on B cells”, S.-F. Han, Brian E. Collins and James C. Paulson. Frontiers in Modern Carbohydrate Chemistry, 2006, 2-16.
  8. “High-affinity ligand probes of CD22 overcome the threshold set by cis ligands to allow for binding, endocytosis, and killing of B cells”,Brian E. Collins, Ola Blixt, S.-F. Han, Bao Duong, H.-Y. Li, Jay K. Nathan, Nicolai Bovin, and James C. Paulson. Journal of Immunology, 2006, 177: 2994-3003.
  9. “Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking”,S.-F. Han, Brian E. Collins, Per Bengtson, and James C. Paulson. Nature Chemical Biology, 2005, 1, 93-97.
  10. “A facile synthesis of a difluoromethylene analog of aspartyl phosphate for inhibition of L-aspartate dehydrogenase”, S.-F. Han, Roger A. Moore, and Ronald E. Viola. Synlett, 2003, Vol6, 845-846.

Selected Target of Current Interests


韩守法 教授、博士生导师

 
博士(美国Toledo大学,2003)
硕士(北京科学院化学研究所,1999)
学士(北京大学,1996)
博士后(美国cripps研究所)

电话:(0592)2181728 (实验室)
电子邮箱:shoufa@xmu.edu.cn

研究兴趣:抑制艾滋病病毒传播/感染的杀微生物剂的研制;纳米颗粒调节的蛋白对细胞的的转染;生物信号响应的荧光分子/纳米颗粒用于细胞信号传导通路的研究。

 




Shou-Fa HAN Professor

 
Post-doc (2003-2006), The Scripps Research Institute, USA
Ph. D. (2003), The University of Toledo, USA;
M.S. (1999), Institute of Chemistry, Chinese Academyof Science, Beijing
B.S. Beijing University, China.

Research Interests: microbicides against sexual HIV-1 transmission; nanoparticle mediated protein delivery and bioresponsive materials foe cell signaling studies