化学生物学 Chemical Biology
赵玉芬课题组: 生命有机磷化学

Yu-Fen ZHAO — Bioorganic Phosphorus Chemistry

Group Members
Associate Professor Pengxiang Xu (许鹏翔), Associate Professor Guo Tang (唐果), Associate Professor Xueji Wu (吴学记), Associate Professor Yan Liu (刘艳)

Selected Publications

  1. “Stereospecific Coupling of H-Phosphinates and Secondary Phosphine Oxides with Amines and Alcohols: A General Method for the Preparation of Optically Active Organophosphorus Acid Derivatives”, G. Wang, R.-W. Shen, Q. Xu, Goto Midori, Y.-F. Zhao and L.-B. Han, J. Org. Chem. 2010, 75, 3890–3892
  2. “Selective P-P and P-O-P Bond Formations through Copper-Catalyzed Aerobic Oxidative Dehydrogenative Couplings of H-Phosphonates”, Y.-B. Zhou, S.-F. Yin, Y.-X. Gao, Y.-F. Zhao, Midori Goto, and L.-B. Han, Angew. Chem. Int. Ed,., 2010, 49, 6852 –6855
  3. “Genome wide exploration of the origin and evolution of amino acids”, X.-X. Liu, J.-X. Zhang, F. Ni, X. Dong, B.-C. Han, D.-X. Han, Z.-L. Ji, Y.-F. Zhao, BMC Evolutionary Biology, 2010, 10:77
  4. “Copper-Catalyzed Aerobic Oxidative Coupling of Terminal Alkynes with H-Phosphonates Leading to Alkynylphosphonates”, Y.-X. Gao, G. Wang, L. Chen, P.-X. Xu, Y.-F. Zhao, Y.-B. Zhou, and L.-B. Han, J. Am. Chem. Soc., 2009, 131, 7956–7957
  5. “N-phosphorylation of amino acids by trimetaphosphate in aqueous solution—learning from prebiotic synthesis”, F. Ni, S.-T. Sun, C. Huang and Y.-F. Zhao, Green Chemistry, 2009, 11, 569 – 573
  6. “On the Electrophilicity of cyclic acylphosphoramidates (CAPAs) postulated as intermediates”, F. Ni, X. Gao, Z.-X. Zhao, C. Huang, and Y.-F. Zhao, Eur. J. Org. Chem., 2009, 3026–3035.
  7. “Chirality at phosphorus in pentacoordinate spirophosphoranes: stereochemistry by X-ray structure and spectroscopic analysis”, J.-B. Hou, H. Zhang, J.-N. Guo, Y. Liu, P.-X. Xu, Y.-F. Zhao and G. M. Blackburn, Org. Biomol. Chem., 2009, 7, 3020–3023.
  8. “Negative ion electrospray ionization mass spectrometry of nucleoside phosphoramidate monoesters: elucidation of novel rearrangement mechanisms by multistage mass spectrometry incorporating in-source deuterium labeling”, P.-X. Xu, A.-F. Hu, D. Hu, X. Gao, Y.-F. Zhao, Rapid Communications in Mass Spectrometry, 2008, 2 :19, 2977-2983
  9. “Alpha-amino acid behaves differently from beta- or gamma-amino acids as treated by trimetaphosphate”, X. Gao, Y. Liu, P.-X. Xu, Y.-F. Zhao. Amino Acids., 2008, 34, 47-53.
  10. “DNA cleavage function of seryl-histidine dipeptide and its application”, Y. Ma, X. Chen, M. Sun, R. Wan, C.-J. Zhu, Y.-M. Li, Y.-F. Zhao, Amino Acids., 2008, 35, 251-256.
  11. “Novel N, S phenacyl protecting group and its application for peptide synthesis“. G. Tang, T. Ji, A.-F. Hu, Y.-F. Zhao, Synthesis Letter, 2008, 12, 1907-1909.
  12. “Variation in proton affinity of the guanidine group between free and blocked arginine”, Y. Liu, L. Jin, J.-B. Hou, P.-X. Xu, Y.-F. Zhao, Amino Acids., 2007, 33, 145-150.
  13. “Electrospray ionization tandem mass spectrometry differentiation of N-phosphoryl-α-,β- andγ-amino acids”. L.-M. Qiang, S.-X. Cao, X.-J. Mao, Y.-C. Guo, X.-C. Liao, Y.-F. Zhao, International Journal of Mass Spectrometry, 2007, 266, 42-49.
  14. “Amino-catalyzed fragmentation characteristics of polyamides containing N-methylpyrrole and N-methylimidazole by electrospray negative ionization mass spectrometry”, M.-Y. Niu, S.-X. Cao, Y. Ye, Z. Zhang, Y.-F.Zhao, Rapid Communications in Mass Spectrometry, 2006, 20, 1077-1081.
  15. “Analysis of the phosphoryl transfer mechanism of c-amp dependent protein kinase (pka) by penta-coodinate phosphoric transition state theory”, F. Ni, W. Li, Y. Li, Y.-F. Zhao, Current Protein & Peptide Science, 2005, 6, 437-442.

Selected Targets of Current Interest


赵玉芬 教授、博士生导师

 
博士(美国纽约州立大学石溪分校,1975)学士(台湾清华大学)
博士后(美国纽约州立大学石溪分校)

中国科学院院士
先后获得中科院科技进步二、三等奖,教育部科技进步二、三等奖,中国青年科学家奖,第二届新世纪巾帼发明家等。

电话:(0592)2185780(实验室)
   (0592)2185610(办公室)
传真:(0592)2186292
电子邮箱:yfzhao@xmu.edu.cn

研究兴趣:生命有机化学,有机磷化学,生命起源,药物化学,化学生物学

 




Yu-Fen ZHAO Professor Fellow of CAS

 
Ph. D. (1975), State University of New York at Stony Brook, USA;
Post-doc (1976-1977), State University of New York at Stony Brook, USA;
B.S. Taiwan Tsinghua University

Research Interests: Bio-Organic Chemistry, Organo-phosphorous Chemistry, Origin of life, Medicinal Chemistry, Chemical Biology

Honors and Awards:
1986 Second Prize of the Chinese Academia Sinica.
1990 Third Prize of the Chinese Academia Sinica.
1993 Chinese National Young Scientist Award (Chemistry).