iChEM例会讲座(22):Mechanics in Cancer Metastasis and Cardiovascular Function

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  • 星期一
  • 4 月24日

题      目: Mechanics in Cancer Metastasis and Cardiovascular Function

讲  座  人: Xin Tang, Postdoctoral Fellow
               Department of Chemistry and Chemical Biology, Harvard University 

时      间: 2017年4月24日下午16:00

地      点: 化学楼234室

Xin Tang is a Postdoctoral Fellow in the Department of Chemistry and Chemical Biology at Harvard University. He was a NSF-IGERT fellow and Mavis Future Faculty fellow, and earned his Ph.D. from University of Illinois at Urbana-Champaign for studying the force-induced cancer metastasis and cardiomyocytes synchrony. His current research focus on in vivo functional imaging, unconventional mechano-electrophysiology, and active matter physics. He will join University of Florida as Assistant Professor from fall, 2017 on.

Mechanical signaling strongly influences embryological development, differentiation, morphogenesis, tissue patterning, and growth as well as various other biological functions. When mechanosensing, mechanotransduction and mechanoresponse are mis-regulated, diseases usually occur. In this talk, I will focus on two examples on how mechanical signals regulate living systems in disease and health, respectively. Firstly, I will discuss how soft matrices can induce human carcinoma cells to undergo a malignant progression. Secondly, I will show that, in living zebrafish, mechanical force can independently trigger calcium wave within vasculature. A quantitative understanding of how force links form and function of living systems will uncover the basic operating principles underlying biological processes, and inspire new technology development for diseases treatment and tissue regeneration.