系 列 学 术 讲 座
题 目 : Supramolecular Chemistry: Anion Receptor Chemistry
讲座人 : Philip A. Gale
The University of Sydney
时 间 : 2018年7月24日（周二）上午10:00-11:30
地 点 : 卢嘉锡楼202报告厅
Anions are ubiquitous in Nature and play crucial roles in a wide range of biological and environmental processes. The second lecture of the series focuses on anion receptor chemistry, the area of research that specialises in binding negatively charged species using artificial molecules. The first part of the lecture covers fundamental aspects in anion receptor chemistry, describing different interactions used for anion binding, design principles for selective anion receptors, Hofmeister series and strategies for binding ion pairs. In the second part, the speaker talks about advances in his research group mainly focusing on selective transmembrane anion transporters. Naturally occurring anion channels and carriers are involved in the transport of small anions such chloride, phosphate and sulfate and thus serve to regulate the flux of key metabolites into and out of cells while maintaining osmotic balance. This lecture will demonstrate how synthetic anion receptors can increase the lipid bilayer permeability to biologically relevant anions mimicking biological transport systems and as a result replace the function of fatty anion channels or disrupt ion gradients for potential therapeutic applications.
Philip A. Gale received his BA (Hons) in 1992 and his MA and DPhil in 1995 from the University of Oxford before moving to the University of Texas at Austin where he spent two years as a Fulbright Scholar. In 1997 he returned to the Inorganic Chemistry Laboratory at Oxford as a Royal Society University Research Fellow. He moved to a Lectureship at the University of Southampton in 1999 and was promoted to Senior Lecturer in 2002, Reader in 2005 and to a Personal Chair in Supramolecular Chemistry in 2007. In 2014 he was awarded a Doctor of Science degree by the University of Oxford and in January 2017 he moved to the University of Sydney to take up the position of Professor of Chemistry and from April 2017 Head of the School of Chemistry. His research interests focus on the supramolecular chemistry of anionic species and in particular the molecular recognition, sensing and lipid bilayer transport of anionic species. Transmembrane anion transporters have potential applications in the development of future treatments for cystic fibrosis and cancer.
【系列讲座二】Supramolecular Chemistry: Anion Receptor Chemistry
系 列 学 术 讲 座