黄培强

最新更新日期:2014-12-18 8:50:33     浏览次数:16768次     
教授、博士生导师
电话:(0592)2180992 (实验室)
   (0592)2182240 (院办)
传真:(0592)2186400
电子邮箱:pqhuang@xmu.edu.cn
更新个人信息
个人简历:
博士 ((法国南巴黎大学,1987)
深入学习文凭(法国蒙彼利埃大学)
学士(厦门大学)
博士后(中国科学院上海有机化学研究所)
英国皇家化学会会士
先后获得国家教委霍英东基金、国家杰出青年科学基金、香港求是科技基金会杰出青年学者奖和中国化学会有机化学委员会有机合成创造奖。
研究兴趣:
有机合成方法学,天然产物(生物碱,信息素等)及药物的不对称合成,多样性导向合成,化学生物学。
近期主要代表论著:
  1. “A New Method for the Construction of the Hydroxylated Tropane Skeleton: Enantioselective Synthesis of (?)-Bao Gong Teng A”, G.-J. Lin, Z. Xiao and P.-Q. Huang*, Chem. Commun. 2011, 47, 1545-1547.
  2. “Asymmetric Synthesis of 5-Alkyl Tetramates and the Asymmetric Total Synthesis of Marine Natural Product Belamide A”, H.-Q. Lan, J.-L. Ye, A.-E. Wang, P.-Q. Huang*, Chem. Eur. J. 2011, 17, 958-968.
  3. “Direct, One-pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents via Lactam/Amide Activation”, K.-J. Xiao, J.-M. Luo, K.-Y. Ye, Y. Wang, and P.-Q. Huang*, Angew. Chem., Int. Ed. 2010, 49, 3037-3040. (highlighted by Nature Chem, and Synfacts).
  4. “A Flexible Approach to 2-Hydroxyalkyl 3-hydroxy-2-pyrrolidinone Derivatives: Concise Asymmetric Syntheses of (+)-1-Epi-Castanospermine and (+)-Castanospermine, and 7-Deoxy-6-epi-castanospermine”, G. Liu, T.-J. Wu, Y.-P. Ruan, P.-Q. Huang* ,Chem. Eur. J. 2010, 16, 5755-5768.
  5. “Asymmetric Synthesis of the Cytotoxic Marine Natural Product (+)-Awajanomycin and Its C-11 Epimer”, R. Fu, J.-L. Ye, X.-J. Dai, Y.-P. Ruan, P.-Q.Huang*, J. Org. Chem. 2010, 75, 4230-4243.
  6. “A Concise and Divergent Approach for the Asymmetric Syntheses of Two Pheromone Components of the Fall Webworm Moth”, Y. Du, J.-F. Zheng, L.-J. Jiang, and P.-Q. Huang*, J. Org. Chem. 2010, 75, 4619-4622.
  7. “NSAID Sulindac and Its Analog Bind RXR? and Inhibit RXR?-Dependent AKT Signaling”, H. Zhou, W. Liu, Y. Su, Z. Wei, J. Liu, S. K. Kolluri, H. Wu, Y.Cao, J.-B. Chen,Y. Wu, T.-D. Yan, X.-H. Cao, W.-W. Gao, A. Molotkov, F.-Q. Jiang, W.-G. Li, B.-Z. Lin, H.-P. Zhang, J.-H. Yu, S.-P. Luo, J.-Z. Zeng, G. Duester, P.-Q. Huang, and X.-K. Zhang*, Cancer Cell 2010, 17, 560-573 (featured article).
  8. “First Asymmetric Synthesis of Cytotoxic Marine Natural Product Palau’imide”, H.-Q. Lan, P.-Q. Huang, Chem. Commun. 2010, 46, 5319-5321.
  9. “Studies towards an Enantioselective Total Synthesis of Sarain A: A Concise Asymmetric Construction of the Diazatricyclic Core”, R.-F. Yang, P.-Q. Huang, Chem. Eur. J. 2010, 16, 10319-10322.
  10. “Efficient and chemoselective alkylation of amines/amino acids using alcohols as alkylating reagents under mild conditions”, C.-P. Xu, Z.-H. Xiao, B.-Q. Zhuo, Y.-H. Wang and P.-Q. Huang*, Chem. Commun. 2010, 41, 7834-7836.
  11. “Versatile One-pot Reductive Alkylation of Lactams/Amides via Amide Activation: Application to the Concise Syntheses of Bioactive Alkaloids (±)-Bgugaine, (±)-Coniine, (+)-Preussin, and (–)-Cassine”, K.-J. Xiao, Y. Wang, K.-Y. Ye, and P.-Q. Huang*, Chem. Eur. J. 2010, 16, 12792-12796.
  12. “One-pot Cross-coupling of N-Acyl N,O-Acetals with ?,?-Unsaturated Compounds”, Y.-G. Xiang, X.-W. Wang, X. Zheng*,Y.-P. Ruana and P.-Q. Huang*, Chem. Commun. 2009, 7045-7047.
  13. “Asymmetric Syntheses and Wnt Signal Inhibitory Activity of Melleumin A and Four Analogues of Melleumins A, B”, J.-M. Luo, C.-F. Dai, and P.-Q. Huang* ,Chem. Asian J. 2009, 4, 328-335.
  14. “Asymmetric Synthesis of Hydroxylated Pyrrolidines, Piperidines and Related Bioactive Compounds: from N-Acyliminium Chemistry to N-?-Carbanion Chemistry”, P.-Q. Huang, Synlett 2006, 1133-1147. (Account)
  15. “Asymmetric Synthesis of Five-Membered Ring Heterocycles” in “Asymmetric Synthesis of Nitrogen Heterocycles”, Contributed chapter: P.-Q. Huang, Ed. Royer, J. Wiley-VCH, Weinheim: 2009

Developed Methods and Selected Targets of Current Interest


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