黄培强

最新更新日期:2018-4-29 17:15:35     浏览次数:29323次     
教授、博士生导师
电话:(0592)2182240 
传真:(0592)2189959
电子邮箱:pqhuang@xmu.edu.cn
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个人简历:
博士 ((法国南巴黎大学,1987)
深入学习文凭(法国蒙彼利埃大学)
学士(厦门大学)
博士后(中国科学院上海有机化学研究所)

英国皇家化学会Fellow(2006)。国家杰出青年科学基金(1996)、香港“求是”科技基金会“杰出青年学者奖”(1997)和霍英东基金获得者(1992),入选新世纪百千万人才工程国家级人选(2006)。享受国务院特殊津贴专家(1993-),福建省优秀专家(2002年),先后获得中国化学会“庆祝中国化学会成立六十周年优秀青年化学奖”(1992),首届福建省“五四”奖章(1998),中国化学会有机化学学科委员会有机合成贡献奖(2007),福建卢嘉锡教育基金会优秀导师奖(2016),《中国科学:化学》2015年和2016年度优秀编委。合作项目“重要森林叶蜂生态学及综合调控技术” 获第七届梁希林业科学技术奖国家二等奖(2016,排名第五)。“手性酰胺的高选择性合成与高效转化及其应用”项目获得高等学校科研究优秀成果奖自然科学二等奖(2017,排名第一)。

研究兴趣:
有机合成方法学,天然产物(生物碱,信息素等)及药物的不对称合成,多样性导向合成,化学生物学。
近期主要代表论著:
  1. 1.   Chen-Xi Ye, Yared Yohannes Melcamu, Heng-Hui Li, Jiang-Tao Cheng, Tian-Tian Zhang, Yuan-Ping Ruan, Xiao Zheng,* Xin Lu,* and Pei-Qiang Huang,* Dual Catalysis for Enantioselective Convergent Synthesis of Enantiopure Vicinal Amino Alcohols, Nature Commun. 20189:410.

    2.   Pei-Qiang Huang,* and Hui Geng, Ni-Catalyzed Chemoselective Alcoholysis of N-Acyloxazolidinones, Green Chem. 201820, 593-599.

    3.   Pei-Qiang Huang* and Hang Chen, Ni-Catalyzed Cross-Coupling Reactions of N-Acylpyrrole-Type Amides with Organoboron Reagents, Chem. Commun. 201753, 12584 – 12587. 

    4.   Huang, Pei-Qiang; Huang, Ying-Hong; Geng, Hui; Ye, Jian-Liang. Metal-Free C-H Alkyliminylation and Acylation of Alkenes with Secondary Amides. Sci. Rep. 2016, 6, 28801.

    5.   Guo, Lian-Dong; Huang, Xiong-Zhi; Luo, Shi-Peng; Cao, Wen-Sen; Ruan, Yuan-Ping; Ye, Jian-Liang; Huang, Pei-Qiang. Organocatalytic, Asymmetric Total Synthesis of (-)-Haliclonin A. Angew. Chem., Int. Ed. 2016, 55, 4064-4068.

    6.   Zheng, Xiao; He, Jiang; Li, Heng-Hui; Wang, Ao; Dai, Xi-Jie; Wang, Ai-E; Huang, Pei-Qiang. Titanocene(III)-Catalyzed Three-Component Reaction of Secondary Amides, Aldehydes, and Electrophilic Alkenes. Angew. Chem., Int. Ed. 2015, 54, 13739-13742.

    7.   Zheng, Xiao; Dai, Xi-Jie; Yuan, Hong-Qiu; Ye, Chen-Xi; Ma, Jie; Huang, Pei-Qiang. Umpolung of Hemiaminals: Titanocene-Catalyzed Dehydroxylative Radical Coupling Reactions with Activated Alkenes. Angew. Chem., Int. Ed. 2013, 52, 3494-3498.

    8.   Xiao, Kai-Jiong; Wang, Ai-E; Huang, Pei-Qiang. Direct Transformation of Secondary Amides into Secondary Amines: Triflic Anhydride Activated Reductive Alkylation. Angew. Chem., Int. Ed. 2012, 51, 8314-8317.

    9.   Xiao, Kai-Jiong; Luo, Jie-Min; Ye, Ke-Yin; Wang, Yu; Huang, Pei-Qiang. Direct, One-pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents through Lactam/Amide Activation. Angew. Chem., Int. Ed. 2010, 49, 3037-3040.

    10.  Wang, Wei-jia; Hou, Pei-pei; Li, Feng-wei; Zhou, Bo; Chen, Hang-zi; Bian, Xue-li; Cai, Qi-xu; Xing, Yong-zhen; He, Jian-ping; Zhang, Hongkui; Huang, Pei-qiang; Lin, Tianwei; Wu, Qiao. Induction of Autophagic Death in Cancer Cells by Agonizing TR3 and Attenuating Akt2 Activity. Chem. Biol. 2015, 22, 1040-1051.

    11.  Li, Li; Liu, Yuan; Chen, Hang-zi; Li, Feng-wei; Wu, Jian-feng; Zhang, Hong-kui; He, Jian-ping; Xing, Yong-zhen; Chen, Yan; Wang, Wei-jia; Tian, Xu-yang; Li, An-zhong; Zhang, Qian; Huang, Pei-qiang; Han, Jiahuai; Lin, Tianwei; Wu, Qiao. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat. Chem. Biol. 2015, 11, 339-346.

    12.  Wang, Wei-jia; Wang, Yuan; Chen, Hang-zi; Xing, Yong-zhen; Li, Feng-wei; Zhang, Qian; Zhou, Bo; Zhang, Hong-kui; Zhang, Jie; Bian, Xue-li; Li, Li; Liu, Yuan; Zhao, Bi-xing; Chen, Yan; Wu, Rong; Li, An-zhong; Yao, Lu-ming; Chen, Ping; Zhang, Yi; Tian, Xu-yang; Beermann, Friedrich; Wu, Mian; Han, Jiahuai; Huang, Pei-qiang; Lin, Tianwei; Wu, Qiao. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat. Chem. Biol. 2014, 10, 133-140.

    13.  Zhan, Yan-yan; Chen, Yan; Zhang, Qian; Zhuang, Jia-jia; Tian, Min; Chen, Hang-zi; Zhang, Lian-ru; Zhang, Hong-kui; He, Jian-ping; Wang, Wei-jia; Wu, Rong; Wang, Yuan; Shi, Chunfang; Yang, Kai; Li, An-zhong; Xin, Yong-zhen; Li, Terytty Yang; Yang, James Y.; Zheng, Zhong-hui; Yu, Chun-dong; Lin, Sheng-Cai; Chang, Chawnshang; Huang, Pei-qiang; Lin, Tianwei; Wu, Qiao. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK. Nat. Chem. Biol. 2012, 8, 897-904.

    14.  Liu, Jing-jing; Zeng, Hui-ni; Zhang, Lian-ru; Zhan, Yan-yan; Chen, Yan; Wang, Yuan; Wang, Juan; Xiang, Shao-hua; Liu, Wen-jun; Wang, Wei-jia; Chen, Hang-zi; Shen, Yue-mao; Su, Wen-jin; Huang, Pei-qiang; Zhang, Hong-kui; Wu, Qiao. A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro. Cancer Res. 2010, 70, 3628-3637.

    15.  Chen, Liqun; Wang, Zhi-Gang; Aleshin, Alexander E.; Chen, Fan; Chen, Jiebo; Jiang, Fuquan; Alitongbieke, Gulimiran; Zeng, Zhiping; Ma, Yue; Huang, Mingfeng; Zhou, Hu; Cadwell, Gregory; Zheng, Jian-Feng; Huang, Pei-Qiang; Liddington, Robert C.; Zhang, Xiao-kun; Su, Ying. Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem. Biol. 2014, 21, 596-607.

    16.  Wang, Zhi-Gang; Chen, Liqun; Chen, Jiebo; Zheng, Jian-Feng; Gao, Weiwei; Zeng, Zhiping; Zhou, Hu; Zhang, Xiao-kun; Huang, Pei-Qiang; Su, Ying. Synthesis and SAR study of modulators inhibiting tRXR alpha-dependent AKT activation. Eur. J. Med. Chem. 2013, 62, 632-648.

    17.  Zhou, Hu; Liu, Wen; Su, Ying; Wei, Zhen; Liu, Jie; Kolluri, Siva Kumar; Wu, Hua; Cao, Yu; Chen, Jiebo; Wu, Yin; Yan, Tingdong; Cao, Xihua; Gao, Weiwei; Molotkov, Andrei; Jiang, Fuquan; Li, Wen-Gang; Lin, Bingzhen; Zhang, Hai-Ping; Yu, Jinghua; Luo, Shi-Peng; Zeng, Jin-Zhang; Duester, Gregg; Huang, Pei-Qiang; Zhang, Xiao-Kun. NSAID Sulindac and Its Analog Bind RXR alpha and Inhibit RXR alpha-Dependent AKT Signaling. Cancer Cell 2010, 17, 560-573.

    18.  Zhang, Xiao-Kun; Su, Ying; Zhou, Hu; Liu, Wen; Huang, Pei-Qiang. Methods and compositions related to a retinoid receptor-selective pathway. PCT Int. Appl. WO 2011140525 A2, Nov 10, 2011.

    Developed Methods and Selected Targets of Current Interest


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