卓春祥

最新更新日期:2019-6-10 16:48:09     浏览次数:3755次     

教授、博士生导师、课题组长
邮箱:cxzhuo@xmu.edu.cn
办公室:化学化工学院卢嘉锡楼616

更新个人信息
个人简历:
  • 2019.04-至今    厦门大学化学化工学院,教授、博士生导师

  • 2014.12-2019.03 德国马普煤炭所,洪堡学者,博士后(导师:Prof. Alois Fürstner)

  • 2014.07-2014.10 中国科学院上海有机化学研究所,研究助理(导师:游书力 研究员)

  • 2009.09-2014.07中国科学院上海有机化学研究所,博士(导师:游书力 研究员)

  • 2005.09-2009.07 湖南大学化学系,学士

荣誉与获奖情况:

  • 2019 第十五批国家中组部“海外高层次人才引进计划” 青年项目入选者

  • 2017 国家自然科学二等奖(第五完成人)

  • 2016 上海市自然科学一等奖(第五完成人)

  • 2015 中国科学院优秀博士论文

  • 2015 德国洪堡奖学金

  • 2014 中国科学院院长奖学金特别奖

  • 2014 中国科学院优秀毕业生

  • 2013 “Lecture Award” of the Roche and RSC International Chemistry Symposium

  • 2013 “Student Travel Award” of the Roche and RSC International Chemistry        Symposium

  • 2013博士生国家奖学金

  • 2013 M. Braun奖学金

  • 2013 汪猷奖学金

  • 2008 湖南大学大学生创新实验一等奖

  • 2008 本科生国家奖学金


研究兴趣:
有机合成方法学;不对称催化;活性天然产物及药物分子的合成
近期主要代表论著:
  1. 1.Zhuo, C.-X.; Fürstner, A.* Catalysis-based total syntheses of pateamine A and DMDA-Pat A. J. Am. Chem. Soc. 2018, 140, 10514–10523. (Top 20 most downloaded articles in September, 2018)

  2. 2. Zhuo, C.-X.; Fürstner, A.* Concise synthesis of a pateamine A analogue with in vivo anticancer activity based on an iron catalyzed pyrone ring-opening/cross coupling. Angew. Chem. Int. Ed. 2016, 55, 6051-6056.  

  3. 3. Zhuo, C.-X.; Zhang, X.; You, S.-L.* Enantioselective synthesis of pyrrole fused piperazine and piperazinone derivatives via Ir-catalyzed asymmetric allylic amination. ACS Catal. 2016, 6, 5307−5310. (Highlighted by Synfacts 2016, 12, 1043.)

  4. 4.Zhuo, C.-X.; Zhou, Y.; Cheng, Q.; Huang, L.; You, S.-L.* Enantioselective construction of spiroindolines with three contiguous stereogenic centers and chiral tryptamine derivative via the reactive spiroindolenine intermediates. Angew. Chem. Int. Ed. 2015, 54, 14146-14149. (Highlighted by Synfacts 2016, 12, 151.)

  5. 5.Zhuo, C.-X.; Cheng, Q.; Liu, W.-B.; Zhao, Q.; You, S.-L.* Enantioselective synthesis of pyrrole based spiro- and polycyclic derivatives via Ir-catalyzed asymmetric allylic dearomatization and controllable migration reactions. Angew. Chem. Int. Ed. 2015, 54, 8475-8479. (Highlighted by Synfacts 2015, 11, 944.)

  6. 6. Zhuo, C.-X.; Zhou, Y.; You, S.-L.* Highly regio- and enantioselective synthesis of poly-substituted 2H-pyrroles via Pd-catalyzed intermolecular asymmetric allylic dearomatization of pyrroles. J. Am. Chem. Soc. 2014, 136, 6590-6593. [Highlighted by J. Am. Chem. Soc. Spotlights (J. Am. Chem. Soc. 2014, 136, 6511.)] [(Highlighted by the highlight module located on the homepage of JACS (May 5, 2014 – May 15, 2014.)] (Highlighted by Synfacts 2014, 10, 820. & Organic Chemistry Portal)

  7. 7. Zhuo, C.-X.; Zheng, C.; You, S.-L.* Transition-metal catalyzed asymmetric allylic dearomatization reactions. Acc. Chem. Res. 2014, 47, 2558-2573.

  8. 8. Zhuo, C.-X.; You, S.-L.* Palladium-catalyzed intermolecular allylic dearomatization reaction of -substituted-β-naphthol derivatives: scope and mechanistic investigation. Adv. Synth. Catal. 2014, 356, 2020-2028.

  9. 9. Zhuo, C.-X.; You, S.-L.* Palladium-catalyzed intermolecular asymmetric allylic dearomatization reaction of naphthol derivatives. Angew. Chem. Int. Ed. 2013, 52, 10056-10059. (Highlighted by Synfacts 2013, 9, 1308. & Chin. J. Org. Chem. 2013, 33, 2440.)

  10. 10.  Zhuo, C.-X.; Wu, Q.-F; Zhao, Q.; Xu, Q.-L.; You, S.-L.* Enantioselective functionalization of indoles and pyrroles via an in-situ formed spiro-intermediate. J. Am. Chem. Soc. 2013, 135, 8169-8172. (Highlighted by Synfacts 2013, 9, 874.)

  11. 11.  Zhuo, C.-X.; Zhang, W.*; You, S.-L.* Catalytic asymmetric dearomatization reactions. Angew. Chem. Int. Ed. 2012, 51, 12662-12686.

  12. 12.  Zhuo, C.-X.; Liu, W.-B.; Wu, Q.-F.; You, S.-L.* Asymmetric dearomatization of pyrroles via Ir-catalyzed allylic substitution reaction: enantioselective synthesis of spiro-2H-pyrroles. Chem. Sci. 2012, 3, 205-208.

  13. 13. Zheng, C.*; Zhuo, C.-X.; You, S.-L.* Mechanistic insights into the Pd-catalyzed intermolecular asymmetric allylic dearomatization of multisubstituted pyrroles: understanding the remarkable regio- and enantioselectivity. J. Am. Chem. Soc. 2014, 136, 16251-16259.

  14. 14. Ye, K.-Y.; Cheng, Q.; Zhuo, C.-X.; You, S.-L.* An iridium(I) N-heterocyclic carbene complex catalyzes asymmetric intramolecular allylic amination reactions. Angew. Chem. Int. Ed. 2016, 55, 8113-8116.

  15. 15. Wu, Q.-F; Zheng, C.*; Zhuo, C.-X.; You, S.-L.* Highly efficient synthesis and stereoselective migration reactions of chiral five-membered aza-spiroindolenines: scope and mechanistic understanding. Chem. Sci. 2016, 7, 4453-4459.

  16. 16. Zhou, Y.; Zhuo, C.-X.; Gu, Q.; You, S.-L.* Intermolecular dearomatization reaction of pyrroles promoted by silica gel. Adv. Synth. Catal. 2015, 357, 912-916 (VIP).

  17. 17. Wang, S.-G.; Yin, Q.; Zhuo, C.-X.; You, S.-L.* Asymmetric dearomatization of β-naphthols through an amination reaction catalyzed by a chiral phosphoric acid. Angew. Chem. Int. Ed. 2015, 54, 647-650.

  18. 18. Yang, Z.-P.; Zhuo, C.-X.; You, S.-L.* Ruthenium-catalyzed intramolecular allylic dearomatization/migration reaction of indoles and pyrroles. Adv. Synth. Catal. 2014, 356, 1731-1734.

  19. 19. Zhao, Q.; Zhuo, C.-X.; You, S.-L.* Enantioselective synthesis of N-allylindoles via palladium-catalyzed allylic amination/oxidation of indolines. RSC Adv. 2014, 4, 10875-10878.

  20. 20. Xu, Q.-L.; Zhuo, C.-X.; You, S.-L.* Highly enantioselective synthesis of tetrahydrocarbolines via iridium-catalyzed intramolecular Friedel-Crafts type allylic alkylation reactions. Org. Lett. 2013, 15, 5909-5911.

  21. 21. Liu, W.-B.; Zheng, C.; Zhuo, C.-X.; Dai, L.-X.; You, S.-L.* Ir-catalyzed allylic alkylation reaction with N-aryl phosphoramidite ligands: scope and mechanistic studies. J. Am. Chem. Soc. 2012, 134, 4812-4821.

  22. 22. Wu, Q.-F.; Liu, W.-B.; Zhuo, C.-X.; Rong, Z.-Q.; Ye, K.-Y.; You, S.-L.* Iridium-catalyzed intramolecular asymmetric allylic dearomatization of phenols. Angew. Chem. Int. Ed. 2011, 50, 4455-4458.


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