Education:

BS (1997-2001), Material Science,College of Chemistry and Chemical Engineering, Xiamen University
PhD (2001-2007), Organic Chemistry, College of Chemistry and Chemical Engineering, Xiamen University

Research Experience:

Research Associate (2012-2013), Computational Chemistry, Department of Chemistry,The Hong Kong University of Science & Technology, Hong Kong (Prof. Zhenyang Lin)

Visiting Professor (2019-2020), Organic Chemistry, Department of Chemistry and Biochemistry, University of California, Los Angeles, United States (Prof. Kendall N. Houk)

Honors and Awards:

The State Natural Science Award (the Second Prize, 2020, the Second Accomplisher)

Thieme Chemistry Journals Award (2019)

The Top-Notch Young Talents Program of Fujian Province (2020)

Natural Science Award of Fujian Province (the First Prize, 2018, the Second Accomplisher)

Program for New Century Excellent Talents in Fujian Province University (2018)

Teaching Contest for University Young Teachers of Fujian Province (the First Prize, 2014)

Principal Research Interests:
Organometallic Chemistry: 1. Strained Metallacycles with Main Group Elements; 2. Extending Classical Organic Reactions to Organometallic Chemistry; 3. Novel Methodology for Organic Synthesis via Metal Carbene or Metal Carbyne

Selected Recent Publications:

1. 1. Yang, X.; Zhang X.; Cai, Y.; Xia, H.;^* Zhang, H.^* Metallaphosphirenes with σ-Aromaticity: Capture of Phosphorus Atom by Metalla-Aromatics. Angew. Chem. Int. Ed. 2025, e202512214.

2. 2. Zhang, Y.;^† Han, F.;^† Yin, Z.; Cai, Y.; Zhang, X.; Zhang, H.^* Fluorescent Pyridine Phosphonium Salts via Transmutation of Metallabenzenes. Nat Commun 2025, 16, 3632.

3. 3. Zhao, J.; Cai, Y.; Yang, X.; Zhang, H.^* Heavier Group 14 Congeners of Metalla-isobenzenes: Access to Metalla-isosilabenzene and Metalla-isogermabenzene by One-Pot Reactions. Chin. J. Chem. 2024, 42, 1121-1127.

4. 4. Lin, Z.;^† Cai, Y.;^† Zhang, Y.; Zhang, H.;^* Xia, H.^* Heterocyclic Suzuki–Miyaura coupling reaction of metalla-aromatics and mechanistic analysis of site selectivity. Chem. Sci 2023, 14, 1227-1233.

5. 5. Cai, Y.;^† Hua, Y.;^† Lu, Z.; Lan, Q.; Lin, Z.; Fei, J.; Chen, Z.; Zhang, H.;^* Xia, H.^* Electrophilic aromatic substitution reactions of compounds with Craig-Mobius aromaticity. Proc. Natl. Acad. Sci. U. S. A. 2021, 118, e2102310118.

6. 6. Zhang, H.;^* Thogersen, M. K.; Jamieson, C. S.; Xue, X. -S.; Jorgensen, K. A.;^* Houk, K. N.^* Ambimodal Transition States in Diels-Alder Cycloadditions of Tropolone and Tropolonate with N-Methylmaleimide. Angew. Chem. Int. Ed. 2021, 60, 24991–24996.

7. 7. Zhang, H.;^* Novak, A. J. E.; Jamieson, C. S.; Xue, X. -S.; Chen, S.; Trauner, D.;^* Houk, K. N.^* Computational Exploration of the Mechanism of Critical Steps in the Biomimetic Synthesis of Preuisolactone A, and Discovery of New Ambimodal (5 + 2)/(4 + 2) Cycloadditions. J. Am. Chem. Soc. 2021, 143, 6601-6608.

8. 8. Huang, F.; Zheng, X.; Lin, X.; Ding, L.; Zhuo, Q.; Wen, T. B.; Zhang, H.;^* Xia, H.^* Extension of the Simmons–Smith Reaction to Metal-carbynes: Efficient Synthesis of Metallacyclopropenes with σ-Aromaticity. Chem. Sci. 2020, 11, 10159-10166.

9. 9. Zhang, J. -X.; Sheong, F. K. ; Lu, Z. ; Zhang, H.;^* Lin, Z.^* Unexpected Electronic Behavior of Organic Azide and Metal‐Carbyne in Their 1,3‐Dipolar Cycloaddition Reaction. Chin. J. Chem. 2020, 38, 1565-1570.

10. 10. Lu, Z.;^† Zhu, Q.;^† Cai, Y.; Chen, Z.; Zhuo, K.; Zhu, J.; Zhang, H.;^* Xia, H.^* Access to Tetracyclic Aromatics with Bridgehead Metals via Metalla-click Reactions. Sci. Adv. 2020, 6, eaay2535.