Title: Electrochemical Difluoromethylarylation of Alkynes

Author: Peng Xiong, He-Huan Xu, Jinshuai Song, and Hai-Chao Xu*

Summary:

An unprecedented radical difluoromethylarylation reaction of alkynes has been developed by discovering a new difluoromethylation reagent, CF₂HSO₂NHNHBoc. This air-stable and solid reagent can be prepared in one step from commercially available reagents CF₂HSO₂Cl and NH₂NHBoc. The CF₂H radical, generated through ferrocene-mediated electrochemical oxidation, participates in an unexplored alkyne addition reaction followed by a challenging 7-membered ring-forming homolytic aromatic substitution step to afford fluorinated dibenzazepines.

Full Link: https://pubs.acs.org/doi/10.1021/jacs.8b00391