[Angew. Chem. Int. Ed.] Prof. Chuanliu Wu published a paper entitled "Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One-Pot Reaction"-College of Chemistry and Chemical Engineering

[Angew. Chem. Int. Ed.] Prof. Chuanliu Wu published a paper entitled "Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One-Pot Reaction"

Publish Date:11.April 2017 Visted: 192Times

Title: Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One-Pot Reaction

Author: Weidong Liu, Yiwu Zheng, Dr. Xudong Kong, Prof. Christian Heinis, Prof. Yibing Zhao, Prof. Chuanliu Wu*

Abstract:
We report the discovery of a small phenyl molecule with four isosteric thiolate-reactive groups of sequentially varied reactivity. This molecule was exploited in combination with cysteine/penicillamine thiolates of different nucleophilic reactivity for precisely regulated and efficient locking (PROP-locking) of linear peptides into multicyclic topologies through a one-pot reaction. The PROP-locking relies on multistep and sequential thiolate/fluorine nucleophilic substitutions, which is not only rapid but highly specific, thus enabling rapid locking of peptides with high amino acid diversities without protecting groups. Several tricyclic peptide templates and bioactive peptides were designed and synthesized using the PROP-locking strategy. We believe that tricyclic peptides precisely locked through stable thioether bonds should be promising structurally constrained scaffolds for developing potential therapeutics and target ligands.

Full Link: http://onlinelibrary.wiley.com/doi/10.1002/anie.201610942/abstract

Research Highlights

[Angew. Chem. Int. Ed.] Prof. Chuanliu Wu published a paper entitled "Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One-Pot Reaction"