[J. Am. Chem. Soc.] Prof. Hai-Chao Xu pulished a paper entitled "Metal- and Reagent-Free Intramolecular Oxidative Amination of Tri- and Tetrasubstituted Alkenes"-College of Chemistry and Chemical Engineering

[J. Am. Chem. Soc.] Prof. Hai-Chao Xu pulished a paper entitled "Metal- and Reagent-Free Intramolecular Oxidative Amination of Tri- and Tetrasubstituted Alkenes"

Publish Date:03.March 2017 Visted: Times

Title: Metal- and Reagent-Free Intramolecular Oxidative Amination of Tri- and Tetrasubstituted Alkenes

Author: Peng Xiong, He-Huan Xu, and Hai-Chao Xu*

Abstract:
A metal- and reagent-free, electrochemical intramolecular oxidative amination reaction of tri- and tetrasubstituted alkenes has been developed. The electrosynthetic method proceeds through radical cyclization to form the key C–N bond, allowing a variety of hindered tri- and tetrasubstituted olefins to participate in the amination reaction. The result is the efficient synthesis of a host of alkene-bearing cyclic carbamates and ureas and lactams.

View Link: http://pubs.acs.org/doi/abs/10.1021/jacs.7b01016

Address：College of Chemistry and Chemical Engineering, Xiamen University, Fujian Province
Zipcode：361005 Tel:0592-2186405 E-mail：chem-xmu@xmu.edu.cn
Copyright © College of Chemistry and Chemical Engineering 2023 All Rights Reserved

Research Highlights

[J. Am. Chem. Soc.] Prof. Hai-Chao Xu pulished a paper entitled "Metal- and Reagent-Free Intramolecular Oxidative Amination of Tri- and Tetrasubstituted Alkenes"