Direct, One-pot Sequential Reductive Alkylation of Lactams/Amides with Grignard and Organolithium Reagents through Lactam/Amide Activation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION , 49, 1-5, Published: 2010
Author: Kai-Jiong Xiao, Jie-Min Luo, Ke-Yin Ye, Yu Wang, and Pei-Qiang Huang*
Abstract：Be dazzled by the sequence: The first efficient and general one-pot method for the reductive bisalkylation of lactams/amides with Grignard and organolithium reagents has been developed (see scheme; DTBMP=2,6-di-tert-butyl-4-methylpyridine, Tf=trifluoromethanesulfonyl).
