Title: Iridium-Catalyzed Reductive Alkylations of Secondary Amides
Author: Wei Ou, Feng Han, Xiu-Ning Hu, Hang Chen, and Pei-Qiang Huang*
Summary:
Reported herein is the first direct, metal-catalyzed reductive functionalization of secondary amides to give
functionalized amines and heterocycles. The method is shown to have exceptionally broad scope with respect to
suitable nucleophiles, which cover both hard and soft C nucleophiles as well as a P nucleophile. The reaction exhibits good chemoselectivity and tolerates several sensitive functional groups.
Full Link：https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201806747
