Education:
University of Florida, Ph.D. in Analytical Chemistry,May 2011 Gainesville, FL
Peking University, B. S. Chemistry, 2006Beijing, China

Principal Research Interests:

bioanalytical chemistry, molecular recognition, signal amplification，microfluidics, micro-nano devices, point-of-care testing.

Selected Recent Publications:

1. [1] Yu, X; Lyu, M; Tu, Y; Pei, Y; Ke, Y; Zhu, M; Liu, Y; Dong, H; Zhou, Z; Niu, Q; Song, J; Yang, C; Zhang, H*; Zhu, Z*. “Dual-Spatially Confined Assembly of DNA Nanowall Stiffens Tumor Cells to Enhance Adoptive T‑Cell Immunotherapy.” J. Am. Chem. Soc. 2026, DOI: 10.1021/jacs.6c00792

2. [2] Zhu, H; Zhang, G; Ning, Y; Zhang, Y; Wu, Y; Li, J; Zhang, H; Yang, C; Zhu, Z*. “Tetrahedral Deoxyribonucleic Acid-Engineered Multivalent Lysosome-Targeting Chimera for Enhanced and Dual Membrane Protein Degradation.” ACS Nano, 2025, 27, 24895-24903

3. [3] Mo, M; Wang, F; Zhang, H; Zhang, Y; Yang, C; Shang, J*; Zhu, Z*. “Membrane-Bounded Intracellular E3 Ubiquitin Ligase-Targeting Chimeras (MembTACs) for Targeted Membrane Protein Degradation.” Angew. Chem. Int. Ed., 2025, 64, e202501857.

4. [4] Zhang, G; Huang, X; Gong, Y; Ding, Y; Wang, H; Zhang, H; Wu, L; Su, R; Yang, C; Zhu, Z*. “Fingerprint Profiling of Glycans on Extracellular Vesicles via Lectin-Induced Aggregation Strategy for Precise Cancer Diagnostics.” J. Am. Chem. Soc. 2024, 146, 29053-29063.

5. [5] Liu, W; Huang, S; Guo Y; Li, X; Dong, H; Li, J; Yang, C; Zhu, Z*. “Deciphering molecular response of cell-cell interactions at the single-cell level by precise on-demand cell assembly.” Science Bulletin, 2024, 69, 2342-2345.

6. [6] Zhang, G; Wang, Y; Zhou, W; Lei, Y; Lu, J; Yin, W*; Zhu, Z*; Yang, C*; Zhang, P*. “A Magnetically Driven Tandem Chip Enables Rapid Isolation and Multiplexed Profiling of Extracellular Vesicles” Angew. Chem. Int. Ed., 2023, 62, e202315113.

7. [7] Chen, Y; Zhao, M; Ouyang, Y; Zhang, S; Liu, Z; Wang, K; Zhang, Z; Liu, Y; Yang, C; Sun, W*; Shen, J*; Zhu, Z*. “Biotemplated precise assembly approach toward ultra-scaled high-performance electronics.” Nature Protocols, 2023, 18, 2975-2997.

8. [8] Yu, X; Lin, W; Lai, Q; Song, J; Liu, Y; Su, R; Niu, Q; Yang, L; Yang, C; Zhang, H*; Zhu, Z*. “ARMOR: Auto-Assembled Resilient Biomimetic Calcified Ornaments for Selective Cell Protection by Dual-Aptamer-Driven Hybridization Chain Reaction.”Angew. Chem. Int. Ed., 2023, 62, e202301083.

9. [9] Wu, Y; Lin, B; Lu, Y; Li, L; Deng, K; Zhang, S; Zhang, H; Yang, C; Zhu, Z*. “Aptamer-LYTACs for Targeted Degradation of Extracellular and Membrane Proteins.” Angew. Chem. Int. Ed., 2023, 62, e202218106.

10. [10] Wang, J; Li, L; Zhang, Y; Zhao, K; Chen, X; Shen, H; Chen, Y; Song, J; Ma, Y; Yang, C; Ding, H*; Zhu, Z*. “Synergetic Collision and Space Separation in Microfluidic Chip for Efficient Affinity-Discriminated Molecular Selection.” Proc. Natl. Acad. Sci. U.S.A., 2022, 119, e2211538119.

11. [11] Chen, Y; Yang, C; Zhu, Z*; Sun, W*. “Suppressing high-dimensional crystallographic defects for ultra-scaled DNA arrays.” Nat. Commun., 2022, 13, 2707.

12. [12] Lin, S; Ze, H; Zhang, X-G; Zhang, Y-J; Song, J; Zhang, H; Zhong, H-L; Yang, Z-L; Yang, C; Li, J-F; Zhu, Z.* “Direct and Simultaneous Identification of Multiple Mitochondrial Reactive Oxygen Species in Living Cells Using a SERS Borrowing Strategy.”Angew. Chem. Int. Ed., 2022, 61, e202203511.

13. [13] Zhao, M; Chen, Y; Wang, K; Zhang, Z; Streit J K; Fagan, J A; Tang, J; Zheng, M; Yang, C; Zhu, Z*; Sun, W*. “DNA-directed nanofabrication of high-performance carbon nanotube field-effect transistors.” Science, 2020, 368, 878-881.

14. [14] Zhu, Z; Yang, C*. “Hydrogel Droplet Microfluidics for High-Throughput Single Molecule/Cell Analysis.” Acc. Chem. Res., 2017, 50, 22–31.

15. [15] Zhu, Z^#; Guan, Z^#; Liu, D^#; Jia, S; Li, J; Lei, Z; Lin, S; Ji, T; Tian, Z; Yang, C*. “Translating Molecular Recognition into a Pressure Signal to enable Rapid, Sensitive, and Portable Biomedical Analysis.” Angew. Chem. Int. Ed., 2015, 54, 10448-10453. (Frontipiece Paper)

16. [16] Zhu, Z^#; Guan, Z^#; Jia, S^#; Lei, Z; Lin, S; Zhang, H; Ma, Y; Tian, Z-Q; Yang, C*. “Au@Pt Nanoparticle Encapsulated Target-responsive Hydrogel with Volumetric Bar-chart Chip Readout for Quantitative Point-of-care Testing.” Angew. Chem. Int. Ed., 2014, 53, 12503–12507.

17. [17] Yan, L^#; Zhu, Z^#; Zou, Y; Huang, Y; Liu, D; Jia, S; Xu, D; Wu, M; Zhou, Y; Zhou, S; Yang, C*. “Target-responsive ‘Sweet’ Hydrogel with Glucometer Readout for Portable and Quantitative Detection of Non-glucose Targets.” J. Am. Chem. Soc., 2013, 135, 3748-3751. (Cover paper & JACS Spotlights)

18. [18] Han, D^#; Zhu, Z^#; Wu, C; Peng, L; Zhou, L; Gulbakan, B; Zhu, G; Williams, K R; Tan, W*. “A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer–Protein Interactions.” J. Am. Chem. Soc., 2012, 134, 20797-20804. (ACS C&EN News)

19. [19] Zhu, Z; Wu, C; Liu, H; Zou, Y; Zhang, X; Kang, H; Yang, C*; Tan, W*. “An Aptamer Cross-linked Hydrogel as a Colorimetric Platform for Visual Detection.” Angew. Chem. Int. Ed., 2010, 49, 1052-1056. (Frontipiece Paper)

20. [20] Zhu, Z; Tang, Z; Phillips, J A; Yang, R; Wang, H; Tan, W*. “Regulation of Singlet Oxygen Generation Using Single-Walled Carbon Nanotubes.” J. Am. Chem. Soc., 2008, 130, 10856-10857.