Office: LU Jia-xi Building 532　
Tel: 2187601　
Email: cyyang@xmu.edu.cn
Address: State Key Laboratory of Physical Chemistry of Solid Surfaces
Homepage: http://www.yang-lab.com/

Education:
B.S., 1998, Xiamen University;
M.S., 2001, Xiamen University;
Ph.D., 2006, University of Florida, U.S.A.

Principal Research Interests:
High-Throughput Single-Cell Spatiotemporal Transcriptomics Sequencing; Applications of Microfluidic Technology in Biomedicine; Cell Recognition, Enrichment, and Imaging; Biomedical Instrumentation

Selected Recent Publications:

1. Cao,  J; Zheng,  Z; Sun, D; Chen, X; Cheng, R; Lv, T; An, Y; Zheng, J*; Song, J*; Wu, L*; Yang, C*; Decoder-seq enhances mRNA capture efficiency in spatial RNA sequencing. Nat. Biotechnol. 2024, 42, 1735–1746.

2. Liang, S; Ning, Y; Wu, X; Zhang, G; Hou, Y; Wang, R; Xu, X*; Yang, C*; Sensitive and accurate detection of low-frequency mutations via pyrophosphorolysis-activiated selective amplification and MALDI-TOF-MS single-nucleotide resolution identification. J. Am. Chem. Soc. 2025, 147, 36223–36232.

3. Yin, K; Xu, Y; Guo, Y; Zheng, Z; Lin, X; Zhao, M; Dong, H; Liang, D; Zhu, Z; Zheng, J*; Lin, S*; Song, J*; Yang, C*; Dyna-vivo-seq unveils cellular RNA dynamics during acute kidney injury via in vivo metabolic RNA labeling-based scRNA-seq. Nat. Commun. 2024, 15, 9866.

4. Li, K; Lu, X; Liao, J; Chen, H; Lin, W; Zhao, Y; Tang, D; Li, C; Tian, Z; Zhu, Z; Jiang, H; Sun, J*; Zhang, H*; Yang, C*; DNA-DISK: Automated end-to-end data storage via enzymatic single-nucleotide DNA synthesis and sequencing on digital microfluidics. Proc. Natl. Acad. Sci. U. S. A. 2024, 121, e2410164121.

5. Yu, X, Ruan, W; Lin, F; Qian, W; Zou, Y; Liu, Y; Su, R; Niu, Q; Ruan, Q; Lin, W; Zhi Zhu, Zhang, H*; Yang, C*, Digital microfluidics-based digital counting of single-cell copy number variation (dd-scCNV Seq), Proc. Natl. Acad. Sci. U. S. A., 2023, 120, e2221934120.

6. Lin, S^#, Yin, K^#, Zhang, Y^#, Lin, F^#, Chen, X; Zeng, X; Guo, X; Zhang, H; Song, J*, Yang, C*. Well-TEMP-seq as a microwell-based strategy for massively parallel profiling of temporal dynamics in single-cells. Nat. Commun. 2023, 14, 1272.

7. Chen, D; Guo, J; Li, A; Sun, C; Lin, H; Lin, H*; Yang, C*; Wang, W*; Gao, J*. Metabolic Fluorine Labeling and Hotspot Imaging of Dynamic Gut Microbiota in Mice. Sci. Adv. 2023, 9, eabg6808.

8. Guo, X; Lin, F; Yi, C; Song, J; Sun, D; Lin, L; Zhong, Z; Wu, Z; Wang, X; Zhang, Y; Li, J; Zhang, H*; Liu, F*; Yang, C*; Song, J*; Deep transfer learning enables lesion tracing of circulating tumor cells. Nat. Commun. 2022, 13, 7687.

9. Niu, Q^#; Gao, J^#; Zhao, K^#; Chen, X; Lin, X; Huang, C; An, Y; Xiao, X; Wu, Q; Cui, L*; Zhang, P*; Wu, L*; Yang, C*, Fluid Nanoporous Microinterface Enables Multiscale-Enhanced Affinity Interaction for Tumor-Derived Extracellular Vesicle Detection. Proc. Natl. Acad. Sci. U. S. A. 2022, 119, e2213236119.

10. Lin, L^#; Zhang, Y^#; Qian, W^#; Liu, Y; Zhang, Y; Lin, F; Liu, C; Lu, G; Sun, D; Guo, X; Song, Y; Song, J*; Yang, C*; Li, J*, LINEAGE: Label-free identification of endogenous informative single-cell mitochondrial RNA mutation for lineage analysis, Proc. Natl. Acad. Sci. U. S. A. 2022, 119, e2119767119.

11. Sun, M; Liu, S; Wei, X; Wan, S; Huang, M; Song, T; Lu, Y; Weng, X; Zhu, L; Chen, H*; Song, Y*; Yang, C*; Aptamer Blocking Strategy Inhibits SARS-CoV-2 Virus Infection, Angew. Chem. Int. Ed. 2021, 60, 2-9. (hot paper)

12. Lin, B; Tian, T; Lu, Y; Liu, D; Huang, M; Zhu, L; Zhu, Z; Song, Y*; Yang, C*; Tracing Tumor-derived Exosomal PD-L1 by Dual-aptamer Activated Proximity-induced Droplet Digital PCR, Angew. Chem. Int. Ed. 2021, 60, 7582-7586.

13. Wu, L; Wang, Y; Xu,X; Liu, Y; Lin, B; Zhang, M, Zhang, J; Wan, S; Yang, C*; Tan, W*; Aptamer-Based Detection of Circulating Targets for Precision Medicine, Chem. Rev. 2021, 121, 12035–12105.

14. Huang, M^#; Li,T^#; Xu, Y; Wei, X; Song, J; Lin,B; Zhu, Z; Song, Y*; and Yang, C*; Activation of Aptamers with Gain-of-Function by Small-Molecule Clipping of Intramolecular Motifs, Angew. Chem. Int. Ed. 2021, 60, 6021-6028.

15. Ruan, Q; Ruan, W; Lin, X; Wang, Y; Zou, F; Zhou, L; Zhu, Z; Yang, C*; Digital-WGS: Automated, Highly Efficient Whole-genome Sequencing of Single Cells by Digital Microfluidics, Sci. Adv. 2020, 6: eabd6454.

16. Lin, L; Wu, Q; Song, J; Du, Y; Gao, J; Song, Y; Wang, W*; Yang, C*; Revealing the in vivo Growth and Division Patterns of Mouse Gut Bacteria, Sci. Adv. 2020, 6: eabb2531.

17. Wang, W*; Zhang, N; Du, Y; Gao, J; Li, M; Lin, L; Czajkowsky, D; Li, X*; Yang, C*; Shao, Z. Three-dimensional Quantitative Imaging of Native Microbiota Distribution in the Gut. Angew Chem. Int. Ed. 2021, 60, 3055-3061.

18. Zhang, J; Lin, B; Wu, L; Huang, M; Li, X; Zhang, H; Song, J; Wang, W; Zhao, G*; Song, Y*; Yang, C*; DNA Nanolithography Enables Highly Ordered Recognition Interface in Microfluidic Chip for Efficient Capture and Release of Circulating Tumor Cells, Angew. Chem. Int. Ed. 2020, 59, 14115-14119.

19. Lin, L; Song, J; Du, Y; Wu, Q; Gao, J; Song, Y; Yang, C*; Wang, W.*; Quantification of Bacterial Metabolic Activities in the Gut by D-Amino Acid-based in vivo Labeling, Angew. Chem. Int. Ed. 2020, 59, 11923-11926.

20. Zhang, M; Zou, Y; Xu, X; Zhang, X; Gao, M; Song, J; Huang, P; Chen, Q; Zhu, Z; Lin, W; Zare, R; Yang, C*; Highly Parallel and Efficient Single Cell mRNA Sequencing with Paired Picoliter Chambers, Nat. Commun. 2020, 11, 2118.

21. Wu, L; Ding, H; Qu, X; Shi, X; Yang, J; Huang, M; Zhang, J; Zhang, H; Song, J; Zhu, L; Song, Y*; Ma, Y*; Yang, C*; Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability, J. Am. Chem. Soc. 2020, 142, 4800-4806.

22. Huang, M; Yang, J; Wang, T; Song, J; Xia, J; Wu, L; Wang, W; Wu, Q; Zhu, Z; Song, Y*; Yang, C*; Homogeneous, Low-volume, Efficient and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction, Angew. Chem. Int. Ed. 2020, 59, 4800-4805.

23. Wang, W; Yang, Q; Du, Y; Zhou, X; Du, X; Wu, Q; Lin, L; Song, Y; Li, F; Yang, C*; Tan, W*; Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables in vivo Imaging of Gut Microbiota, Angew. Chem. Int. Ed. 2020, 59, 2628-2633.

24. Wang, W; Lin, L; Du, Y; Song, Y; Peng, X; Chen, X*; Yang, C*; Assessing the Viability of Transplanted Gut Microbiota by Sequential Tagging with D-Amino acid-based Metabolic Probes, Nat. Commun. 2019, 10, 1317.

25. Li, Y; Ma, Y; Jiao, X; Li, T; Lv, Z；Yang, C*; Zhang, X*; Wen, Y*; Control of Capillary Behavior Through Target-responsive Hydrogel Permeability Alteration for Sensitive Visual Quantitative Detection, Nat. Commun. 2019, 10, 1036.

26. Song, Y; Shi, Y; Huang, M; Wang, W; Wang, Y; Cheng, J; Lei, Z; Zhu, Z; Yang, C*; Bioinspired Engineering of Multivalent Aptamer-Functionalized Nanointerface to Enhance Capture and Release of Circulating Tumor Cells, Angew. Chem. Int. Ed. 2019, 58, 2236-2240.

27. Chen, Y; Ke, G*; Ma, Y; Zhu, Z; Liu, M; Liu, Y; Yan, H*; Yang, C*; A Synthetic Light-Driven Substrate Channeling System for Precise Regulation of Enzyme Cascade Activity Based on DNA Origami, J. Am. Chem. Soc. 2018, 140, 8990-8996.

28. Gashaw, M; Abate, M; Song, Y; Zhu, Z; Yan, F; Xu, Y; Wang, X; Li, Q; Yang, C*. Isolation, Detection and Antigen Based Profiling of Circulating Tumor Cells Using a Size Dictated Immunocapture Chip, Angew. Chem. Int. Ed. 2017, 56, 10681-10685.

29. Zhu, Z; Yang, C*; Hydrogel Droplet Microfluidics for High-throughput Single Molecule/Cell Analysis, Acc. Chem. Res. 2017, 50, 22-31.

30. Ke, G; Liu, M; Jiang, S; Qi, X; Yang, YR; Wootten, S; Zhang, F; Zhu, Z; Liu, Y; Yang, C*; Yan, H*; Directional Regulation of Enzyme Pathways through the Control of Substrate Channeling on a DNA Origami Scaffold, Angew. Chem. Int. Ed. 2016, 55, 7483-7486.