Chun-Xiang Zhuo

Update Date:2019-04-18     Visited:Times     

Professor of Chemistry
E-mail:cxzhuo@xmu.edu.cn
Address:Department of Chemistry,
College of Chemistry and Chemical Engineering,
Xiamen University, Xiamen, 361005, China
ORCID: https://orcid.org/0000-0002-2805-9632

WEB:  https://zhuolab.xmu.edu.cn/

Education:

  • 2009.09-2014.07 Shanghai Institute of Organic Chemistry, Ph.D. in Organic Chemistry (Advisor: Prof. Shu-Li You)

  • 2005.09-2009.07 Hunan University, B.Sc. in Chemistry


Research Experience:

  • 2019.04- present  Xiamen University, Department of Chemistry, Professor

  • 2014.12-2019.03  Max-Planck-Institut für Kohlenforschung, Postdoctoral Researcher (Advisor: Prof. Alois Fürstner)

  • 2014.07-2014.10  Shanghai Institute of Organic Chemistry, Research Associate (Advisor: Prof. Shu-Li You)

 

Honors and Awards:

  • 2022 Science of Synthesis Early Career Advisory Board

  • 2022 Thieme Chemistry Journals Award

  • 2019 the 15th bath of “Recruitment Program of Global Young Expert”

  • 2017 Second-class 2017 National Natural Science Award

  • 2016 First-class 2016 Shanghai Natural Science Award

  • 2015 Alexander von Humboldt Fellowships for Postdoctoral Researchers

  • 2015 Best Ph.D. Theses of Chinese Academy of Sciences

  • 2014 Special Prize of the CAS President Award

  • 2014 Outstanding Graduates of the Chinese Academy of Sciences

  • 2013 National Scholarship for excellent students

  • 2013 A special award for the outstanding lecture entitled “Transition-metal-catalyzed asymmetric allylic dearomatization reactions” of the Roche and RSC Chemistry Symposium

  • 2013 “Student Travel Award” of the Roche and RSC Chemistry Symposium: leading science for drug discovery

  • 2013 “M. Braun” Scholarship for excellent students

  • 2013 “Wang Yu” Scholarship of SIOC

  • 2008 First-Class Award of Scientific Research held by Hunan University, with the completion of the project “Synthesis of Novel Macroporous Silica Cages with Controllable Frameworks”

  • 2008 National Scholarship for excellent students

 

Principal Research Interests:
Development of novel methodology for organic synthesis; asymmetric catalysis; syntheses of bioactive natural products and drugs

Selected Recent Publications:

  1. 26. Li, J.-T.; Luo, J.-N.; Wang, J.-L.; Wang, D.-K.; Yu, Y.-Z.; Zhuo, C.-X.* Stereoselective intermolecular radical cascade reactions of tryptophans or ɤ-alkenyl-α-amino acids with acrylamides via photoredox catalysis. Nat. commun. 2022, 13, 1778. DOI: 10.1038/s41467-022-29464-5.

  2. 25. Wang, J.-L.; Zhuo, C.-X.*Catalytic deoxygenative cyclopropanation of 1,2-dicarbonyl or monocarbonyl compounds via molybdenum catalysis. Synlett 2022, 33, 599–608. (Invited Synpacts)

  3. 24. Cao, L.-Y.; Luo, J.-N.; Yao, J.-S.; Wang, D.-K.; Dong, Y.-Q.; Zheng, C.; Zhuo, C.-X.* Molybdenum-catalyzed deoxygenative cyclopropanation of 1,2-dicarbonyl or mono-carbonyl compounds. Angew. Chem. Int. Ed. 2021, 60, 15254–15259.

  4. Highlighted by Nature Catalysis 2021, 4, 347.

  5. Highlighted by WileyChem, X-MOL, 研之成理, CBG.

  6. 23. Zhuo, C.-X.; Fürstner, A.* Catalysis-based total syntheses of pateamine A and DMDA-Pat A. J. Am. Chem. Soc. 2018, 140,10514–10523.

  7. Highlighted by Synfacts 2018, 14, 1114.

  8. Top 20 most downloaded articles in September, 2018.

  9. 22. Zhuo, C.-X.; Fürstner, A.* Concise synthesis of a pateamine A analogue with in vivo anticancer activity based on an iron catalyzed pyrone ring-opening/cross coupling. Angew. Chem. Int. Ed. 2016, 55, 6051-6056.

  10. 21. Zhuo, C.-X.; Zhang, X.; You, S.-L.* Enantioselective synthesis of pyrrole fused piperazine and piperazinone derivatives via Ir-catalyzed asymmetric allylic amination. ACS Catal. 2016, 6, 5307−5310.

  11. Highlighted by Synfacts 2016, 12, 1043.

  12. 20. Zhuo, C.-X.; Zhou, Y.; Cheng, Q.; Huang, L.; You, S.-L.* Enantioselective construction of spiroindolines with three contiguous stereogenic centers and chiral tryptamine derivative via the reactive spiroindolenine intermediates. Angew. Chem. Int. Ed. 2015, 54, 14146-14149.

  13. Highlighted by Synfacts 2016, 12, 151.

  14. 19. Zhuo, C.-X.; Cheng, Q.; Liu, W.-B.; Zhao, Q.; You, S.-L.* Enantioselective synthesis of pyrrole based spiro- and polycyclic derivatives via Ir-catalyzed asymmetric allylic dearomatization and controllable migration reactions. Angew. Chem. Int. Ed. 2015,54, 8475-8479.

  15. Highlighted by Synfacts 2015, 11, 944.

  16. 18. Zhuo, C.-X.; Zhou, Y.; You, S.-L.* Highly regio- and enantioselective synthesis of poly-substituted 2H-pyrroles via Pd-catalyzed intermolecular asymmetric allylic dearomatization of pyrroles. J. Am. Chem. Soc. 2014, 136, 6590-6593.

  17. Highlighted by J. Am. Chem. Soc. Spotlights (J. Am. Chem. Soc. 2014, 136, 6511.)

  18. Highlighted by the highlight module located on the homepage of JACS (May 5, 2014 – May 15, 2014.)

  19. Highlighted by Synfacts 2014, 10, 820. &Organic Chemistry Portal.

  20. 17. Zhuo, C.-X.; Zheng, C.; You, S.-L.* Transition-metal catalyzed asymmetric allylic dearomatization reactions. Acc. Chem. Res.2014, 47, 2558-2573.

  21. 16. Zhuo, C.-X.; You, S.-L.* Palladium-catalyzed intermolecular allylic dearomatization reaction of a-substituted-β-naphthol derivatives: scope and mechanistic investigation. Adv. Synth. Catal. 2014, 356, 2020-2028.

  22. 15. Zhuo, C.-X.; You, S.-L.* Palladium-catalyzed intermolecular asymmetric allylic dearomatization reaction of naphthol derivatives. Angew. Chem. Int. Ed. 2013, 52, 10056-10059.

  23. Highlighted by Synfacts 2013, 9, 1308. &Chin. J. Org. Chem. 2013, 33, 2440.

  24. 14. Zhuo, C.-X.; Wu, Q.-F; Zhao, Q.; Xu, Q.-L.; You, S.-L.* Enantioselective functionalization of indoles and pyrroles via an in-situ formed spiro-intermediate. J. Am. Chem. Soc. 2013, 135, 8169-8172.

  25. Highlighted by Synfacts 2013, 9, 874.

  26. 13. Zhuo, C.-X.; Zhang, W.*; You, S.-L.* Catalytic asymmetric dearomatization reactions. Angew. Chem. Int. Ed. 2012, 51, 12662-12686.

  27. 12. Zhuo, C.-X.; Liu, W.-B.; Wu, Q.-F.; You, S.-L.* Asymmetric dearomatization of pyrroles via Ir-catalyzed allylic substitution reaction: enantioselective synthesis of spiro-2H-pyrroles. Chem. Sci. 2012, 3, 205-208.

  28. 11. Zheng, C.*; Zhuo, C.-X.; You, S.-L.* Mechanistic insights into the Pd-catalyzed intermolecular asymmetric allylic dearomatization of multisubstituted pyrroles: understanding the remarkable regio- and enantioselectivity. J. Am. Chem. Soc. 2014,136, 16251-16259.

  29. 10. Ye, K.-Y.; Cheng, Q.; Zhuo, C.-X.; You, S.-L.* An iridium(I) N-heterocyclic carbene complex catalyzes asymmetric intramolecular allylic amination reactions. Angew. Chem. Int. Ed. 2016, 55, 8113-8116.

  30. 9. Wu, Q.-F; Zheng, C.*; Zhuo, C.-X.; You, S.-L.* Highly efficient synthesis and stereoselective migration reactions of chiral five-membered aza-spiroindolenines: scope and mechanistic understanding. Chem. Sci. 2016, 7, 4453-4459.

  31. 8. Zhou, Y.; Zhuo, C.-X.; Gu, Q.; You, S.-L.* Intermolecular dearomatization reaction of pyrroles promoted by silica gel. Adv. Synth. Catal. 2015, 357, 912-916 (VIP).

  32. 7. Wang, S.-G.; Yin, Q.; Zhuo, C.-X.; You, S.-L.* Asymmetric dearomatization of β-naphthols through an amination reaction catalyzed by a chiral phosphoric acid. Angew. Chem. Int. Ed. 2015, 54, 647-650.

  33. 6. Yang, Z.-P.; Zhuo, C.-X.; You, S.-L.* Ruthenium-catalyzed intramolecular allylic dearomatization/migration reaction of indoles and pyrroles. Adv. Synth. Catal. 2014, 356, 1731-1734.

  34. 5. Zhao, Q.; Zhuo, C.-X.; You, S.-L.* Enantioselective synthesis of N-allylindoles via palladium-catalyzed allylic amination/oxidation of indolines. RSC Adv. 2014, 4, 10875-10878.

  35. 4. Xu, Q.-L.; Zhuo, C.-X.; You, S.-L.* Highly enantioselective synthesis of tetrahydrocarbolines via iridium-catalyzed intramolecular Friedel-Crafts type allylic alkylation reactions. Org. Lett. 2013, 15, 5909-5911.

  36. 3. Liu, W.-B.; Zheng, C.; Zhuo, C.-X.; Dai, L.-X.; You, S.-L.* Ir-catalyzed allylic alkylation reaction with N-aryl phosphoramidite ligands: scope and mechanistic studies. J. Am. Chem. Soc. 2012, 134, 4812-4821.

  37. 2. Wu, Q.-F.; Liu, W.-B.; Zhuo, C.-X.; Rong, Z.-Q.; Ye, K.-Y.; You, S.-L.* Iridium-catalyzed intramolecular asymmetric allylic dearomatization of phenols. Angew. Chem. Int. Ed. 2011, 50, 4455-4458.

  38. 1. Xia, J.-B.; Zhuo, C.-X.; You, S.-L.* Synthesis of Cyclopropane-containing Building Blocks via Ir-Catalyzed Enantioselective Allylic Substitution Reaction. Chin. J. Chem. 2010, 28, 1525-1528.