Education:

B.S., Xiamen University

Ph.D., Xiamen University

Principle Research Interests:

Directed Molecular Evolution

Micro-nano Interface Assembly and Recognition Mechanism

Microfluidic Techniques and Analysis

Liquid Biopsy

Single-cell Analysis

Selected Recent Publications:

1. J. Zhang#, Y. Xu#, M. Chen, S. Wang, G. Lin, Y. Huang, C. Yang, Y. Yang*, Y. Song*. Spatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS-CoV-2 Variants. Angew. Chem. Int. Ed. 2024, e202412294.

2. Q. Wu, W. Wang, C. Zhang, Z. You, Y. Zeng, Y. Lu, S. Zhang, X. Li, C. Yang, Y. Song*. Capturing Nascent Extracellular Vesicles by Metabolic Glycan Labeling-Assisted Microfluidics. Nat. Commun. 2023, 14, 6541.

3. Q. Wu#, X. Wei#, F. Chen, M. Huang, S. Zhang, L. Zhu, L. Zhou, C. Yang, Y. Song*. Aptamer-Assisted Blockade of the Immune Suppressor Sialic Acid-Binding Immunoglobulin-Like Lectin-15 for Cancer Immunotherapy. Angew. Chem. Int. Ed. 2023, 62, e202312609.

4. J. Zhang#, Y. Xu#, M. Chen, Y. Huang, T. Song, C. Yang, Y. Yang*, Y. Song*. Elucidating the Effect of Nanoscale Receptor-Binding Domain Organization on SARS-CoV-2 Infection and Immunity Activation with DNA Origami. J. Am. Chem. Soc. 2022, 144, 21295.

5. J. Zhang#, Y. Xu#, Y. Huang, M. Sun, S. Liu, S. Wan, H. Chen, C. Yang, Y. Yang*, Y. Song*. Spatially Patterned Neutralizing Icosahedral DNA Nanocage for Efficient SARS-CoV-2 Blocking. J. Am. Chem. Soc. 2022, 144, 13146.

6. M. Sun#, S. Liu#, T. Song, F. Chen, J. Zhang, J. Huang, S. Wan, Y. Lu, H. Chen*, W. Tan*, Y. Song*, C. Yang*. Spherical Neutralizing Aptamer Inhibits SARS-CoV‑2 Infection and Suppresses Mutational Escape. J. Am. Chem. Soc. 2021, 143, 21541.

7. L. Zhu, Y. Xu, X. Wei, H. Lin, M. Huang, B. Lin, Y. Song*, C. Yang*. Coupling Aptamer-based Protein Tagging with Metabolic Glycan Labeling for In Situ Visualization and Biological Function Study of Exosomal Protein-Specific Glycosylation. Angew. Chem. Int. Ed. 2021, 60, 18111.

8. M. Sun, S. Liu, X. Wei, S. Wan, M. Huang, T. Song, Y. Lu, X. Weng, L. Zhu, H. Chen*, Y. Song*, C. Yang*. Aptamer Blocking Strategy Inhibits SARS-CoV-2 Virus Infection. Angew. Chem. Int. Ed. 2021, 60, 10266.

9. B. Lin, T. Tian, Y. Lu, D. Liu, M. Huang, L. Zhu, Z. Zhu, Y. Song*, C. Yang*. Tracing Tumor-derived Exosomal PD-L1 by Dual-aptamer Activated Proximity-induced Droplet Digital PCR. Angew. Chem. Int. Ed. 2021, 60, 7582.

10. M. Huang#, T. Li#, Y. Xu, X. Wei, J. Song, B. Lin, Z. Zhu, Y. Song*, C. Yang*. Activation of Aptamers with Gain-of-Function by Small-Molecule Clipping of Intramolecular Motifs. Angew. Chem. Int. Ed. 2021, 60, 6021.