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杨朝勇

发布日期:2018-06-23     浏览次数:次   

教授、博士生导师
TEL: （0592）2187621 （实验室）
　　  （0592）2187601 （办公室）
FAX: （0592）2189959
EMAIL: cyyang@xmu.edu.cn  

个人简历：
学士（厦门大学，1998）
硕士（厦门大学，2001）
博士（美国佛罗里达大学，2006）
博士后（美国加州大学伯克利分校, 2006-2007）

任Analytical Chemistry执行主编（2025-）Analytical Chemistry 副主编（2023-2025）、Current Protocols 副主编（2025-）、ACS Applied Bio Materials副主编（2018-2022）、中国分析测试协会核酸分析分会主任、中国化学会化学生物学学科委员会副主任、中国生物物理学会微流控系统分会副会长、中国微米纳米技术学会微纳流控技术分会副理事长、中国化学会分子医学专业委员会秘书长。

近年主持主要科研项目包括：国家基金委创新群体研究群体项目、国家基金委重大项目课题、教育部学科突破先导项目课题、国家重大科研仪器研制项目、科技部国家重点研发计划合成生物学重点专项课题、国家自然科学基金委重点项目、国家杰出青年科学基金、科技部973课题、科技部国家重大科学仪器设备开发专项子任务、国家自然科学基金委面上项目等。

获得美国化学会分析化学研究生奖、中国政府优秀自费留学生奖、中美化学与化学生物学教授协会杰出教授奖、福建省青年科技奖、福建省杰出青年基金、国家杰出青年科学基金、福建省高校领军人才、福建省科技创新领军人才、厦门市双百计划领军型创业人才、江苏省“双创人才”、日本东京大学讲座教授奖、英国皇家化学会会士、中国青年分析化学家奖、中国化学会-英国皇家化学会青年化学奖、科技部中青年科技创新领军人才、中组部等9部委《全民科学素质行动计划纲要》实施工作先进个人、福建省科技进步一等奖、美国化学会测量科学进展讲座奖、厦门市科技进步一等奖、上海市科技进步奖一等奖等奖项与称号。

在Nature Biotechnol、Chem Rev、Nature Commun、Sci. Adv.、Acc Chem Res、PNAS、JACS等刊物发表论文400余篇，论文被引超过26000次，H指数84。获授权专利90余项。


研究兴趣：

单细胞时空组学测序、液体活检、微流控芯片、功能核酸、智能仪器与器件


近期主要代表论著：

  1. 1. Wen, Q; Na, X; Lu, Y; Zhang, Q; Zha, Z; Zhao, H; Zhang, G; Wu, Q; Liu, X; Zhu, Z; Yang, Q; Song, Y*; Xu, X*; Yang, C*; Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-Seq. Nat. Biotechnol. 2026, DOI : 10.1038/s41587-026-03192-3

  2. 2. Cao,  J; Zheng,  Z; Sun, D; Chen, X; Cheng, R; Lv, T; An, Y; Zheng, J*; Song, J*; Wu, L*; Yang, C*; Decoder-seq enhances mRNA capture efficiency in spatial RNA sequencing. Nat. Biotechnol. 2024, 42, 1735–1746.

  3. 3. Wang, S; Yin, K; Song, J; Lin, S*; Yang, C*; Simultaneous Measurement of RNA Synthesis and Degradation Rates in Single Cells Unveils the Regulatory Mechanisms of Temporal RNA Dynamics. Angew. Chem. Int. Ed., 2025, 64, e202510939.

  4. 4. Liang, S; Ning, Y; Wu, X; Zhang, G; Hou, Y; Wang, R; Xu, X*; Yang, C*; Sensitive and Accurate Detection of Low-frequency Mutations via Pyrophosphorolysis-Activated Selective Amplification and MALDI-TOF-MS Single-Nucleotide Resolution Identification. J. Am. Chem. Soc., 2025, 147, 36223-36232.

  5. 5. Du, Y; Wang, Y; Yang, M; Lin, L; Zhang, J; Huang, Z; Liu, C; Liu, S; Ma, J*; Yang, C*; Wang, W*; Unusual MurC Ligase and Peptidoglycan Discovered in Lachnospiraceae Using a Fluorescent L-Amino Acid Based Selective Labeling Probe. Angew. Chem. Int. Ed., 2025, 64, e202503049.

  6. 6. Yin, L; Han, X; Guo, F; Zou, Y; Xie, Q*; Wang, J; Yang, C*; Yang, T*; An All-in-One Nanohole Array for Size-Exclusive Trapping and High-Throughput Digital Counting of Single Extracellular Vesicles for Non-Invasive Cancer Screening. Angew. Chem. Int. Ed., 2025, 64, e202506744.

  7. 7. Yin, K; Xu, Y; Guo, Y; Zheng, Z; Lin, X; Zhao, M; Dong, H; Liang, D; Zhu, Z; Zheng, J*; Lin, S*; Song, J*; Yang, C*; Dyna-vivo-seq unveils cellular RNA dynamics during acute kidney injury via in vivo metabolic RNA labeling-based scRNA-seq. Nat. Commun., 2024, 15, 9866.

  8. 8. Li, K; Lu, X; Liao, J; Chen, H; Lin, W; Zhao, Y; Tang, D; Li, C; Tian, Z; Zhu, Z; Jiang, H; Sun, J*; Zhang, H*; Yang, C*; DNA-DISK: Automated end-to-end data storage via enzymatic single-nucleotide DNA synthesis and sequencing on digital microfluidics. Proc. Natl. Acad. Sci. U. S. A., 2024, 121, e2410164121

  9. 9. Chen, Z; Zeng, W; Lei, Y; Liang, W; Yang, X; Yuan, R; Yang, C*; Zhuo, Y*; Engineering of a Multi-Modular DNA Nanodevice for Spatioselective Imaging and Evaluation of NK Cell-Mediated Cancer Immunotherapy. Angew. Chem. Int. Ed., 2024, 64, e202414064

  10. 10. Lin, X; Chen, Y; Lin, L; Yin, K; Cheng, R; Lin, X; Wang, X; Guo, Y; Wu, Z; Zhang, Y; Li, J*; Yang, C*; Song, J*; mitoSplitter: A mitochondrial variants-based method for efficient demultiplexing of pooled single-cell RNA-seq. Proc. Natl. Acad. Sci. U. S. A., 2023, 120, e2307722120

  11. 11. Yu, X, Ruan, W; Lin, F; Qian, W; Zou, Y; Liu, Y; Su, R; Niu, Q; Ruan, Q; Lin, W; Zhi Zhu, Zhang, H* ; Yang, C*, Digital microfluidics-based digital counting of single-cell copy number variation (dd-scCNV Seq), Proc. Natl. Acad. Sci. U. S. A., 2023, 120, e2221934120.

  12. 12. Lei, Y#, Fei, X#, Ding, Y; Zhang, J; Zhang, G; Dong, L; Song, J; Zhuo, Y; Xue, W; Zhang, P*; Yang, C*; Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding. Sci Adv. 2023, 9, eadi1556.

  13. 13. Zhang, G; Wang, Y; Zhou, W ; Lei, Y; Lu, J; Yin, W*; Zhu, Z*; Yang, C*; Zhang, P*; A Magnetically Driven Tandem Chip Enables Rapid Isolation and Multiplexed Profiling of Extracellular Vesicles. Angew. Chem. Int. Ed., 2023, 62, e202315113.

  14. 14. Lin,S; Yin, K; Zhang, Y; Lin, F; Chen, X; Zeng, X; Guo, X; Zhang, H; Song, J*; Yang, C*, Well-TEMP-seq as a microwell-based strategy for massively parallel profiling of single-cell temporal RNA dynamics. Nat. Commun. 2023, 14, 1272

  15. 15. Chen, D; Guo, J; Li, A; Sun, C; Lin, H; Lin, H; Yang, C*; Wang, W*; Gao, J*. Metabolic Fluorine Labeling and Hotspot Imaging of Dynamic Gut Microbiota in Mice. Sci. Adv., 2023, 9, eabg6808.

  16. 16. Chen, H; Su, M; Lei, Y ; Ye, Z; Chen, Z ; Ma, P ; Yuan, R* ; Zhuo, Y*; Yang, C*; Liang, W*; Insights of Life Molecules' Dynamic Distribution in Live Cells via Sequence-Structure Bispecific Fluorescent RNA, J. Am. Chem. Soc, 2023, 145, 12812-12822.

  17. 17. Niu, Q; Gao, J; Zhao, K; Chen, X; Lin, X; Huang, C; An, Y; Xiao, X; Wu, Q; Cui, L*; Zhang, P*; Wu, L*; Yang, C*, Fluid Nanoporous Microinterface Enables Multiscale-Enhanced Affinity Interaction for Tumor-Derived Extracellular Vesicle Detection. Proc. Natl. Acad. Sci. U. S. A., 2022, 119, e2213236119.

  18. 18. Guo, X; Lin, F; Yi, C; Song, J; Sun, D; Lin, L; Zhong, Z; Wu, Z; Wang, X; Zhang, Y; Li, J; Zhang, H*; Liu, F*; Yang, C*; Song, J*; Deep transfer learning enables lesion tracing of circulating tumor cells. Nat. Commun. 2022, 13, 7687.

  19. 19. Lin, L; Zhang, Y; Qian, W; Liu, Y; Zhang, Y; Lin, F; Liu, C; Lu, G; Sun, D; Guo, X; Song, Y; Song, J*; Yang, C*; Li J*, LINEAGE: Label-free identification of endogenous informative single-cell mitochondrial RNA mutation for lineage analysis, Proc. Natl. Acad. Sci. U. S. A, 2022, 119, e2119767119.

  20. 20. Niu, Q#; Gao, J#; Zhao, K#; Chen, X; Lin, X; Huang, C; An, Y; Xiao, X; Wu, Q; Cui, L*; Zhang, P*; Wu, L*; Yang, C*, Fluid Nanoporous Microinterface Enables Multiscale-Enhanced Affinity Interaction for Tumor-Derived Extracellular Vesicle Detection. Proc. Natl. Acad. Sci. U. S. A,, 2022, 119, e2213236119.

  21. 21. Wu, L; Wang, Y; Xu,X; Liu, Y; Lin, B; Zhang, M, Zhang, J; Wan, S; Yang, C*; Tan, W*; Aptamer-Based Detection of Circulating Targets for Precision Medicine, Chem. Rev. 2021, 121, 12035–12105

  22. 22. Zhu, L; Xu, Y; Wei, X; Lin, H; Huang, M; Lin, B; Song, Y*; Yang, C*; Coupling Aptamer-based Protein Tagging with Metabolic Glycan Labeling for In Situ Visualization and Biological Function Study of Exosomal Protein-Specific Glycosylation. Angew. Chem. Int. Ed., 2021, 60, 18111-18115.

  23. 23. Sun, M; Liu, S; Song, T; Chen, F; Zhang, J; Huang, J; Wan, S; Lu, Y; Chen, H*; Tan, W*; Song, Y*; Yang, C*; Spherical Neutralizing Aptamer Inhibits SARS-CoV-2 Infection and Suppresses Mutational Escape, J. Am. Chem. Soc., 2021, 143, 21541-21548.

  24. 24. Sun, M; Liu, S; Wei, X; Wan, S; Huang, M; Song, T; Lu, Y; Weng, X; Lin, Z; Chen, H*; Song, Y*; Yang, C*; Aptamer Blocking Strategy Inhibits SARS-CoV-2 Virus Infection. Angew. Chem. Int. Ed. 2021, 60, 10354-10360.

  25. 25. Lin, B; Tian, T; Lu, Y; Liu, D; Huang, M; Zhu, L; Zhu, Z; Song, Y*; Yang, C*; Tracing Tumor-derived Exosomal PD-L1 by Dual-aptamer Activated Proximity-induced Droplet Digital PCR, Angew. Chem. Int. Ed., 2021, 60, 7582-7586.

  26. 26. Zhang, M; Zou, Y; Xu, X; Zhang, X; Gao, M; Song, J; Huang, P; Chen, Q; Zhu, Z; Lin, W; Zare, R; Yang, C*; Highly Parallel and Efficient Single Cell mRNA Sequencing with Paired Picoliter Chambers. Nat. Commun., 2020, 11, 2118.

  27. 27. Lin, L; Du, Y; Song, J; Wang, W*; Yang, C*. Imaging Commensal Microbiota and Pathogenic Bacteria in the Gut, Acc. Chem. Res., 2021, 54, 2076–2087

  28. 28. Zhang, J; Lin, B; Wu, L; Huang, M; Li, X; Zhang, H; Song, J; Wang, W; Zhao, G*; Song, Y*; Yang, C*; DNA Nanolithography Enables Highly Ordered Recognition Interface in Microfluidic Chip for Efficient Capture and Release of Circulating Tumor Cells, Angew. Chem. Int. Ed., 2020, 59，14115-14119.

  29. 29. Lin, L; Song, J; Du, Y; Wu, Q; Gao, J; Song, Y; Yang, C*; Wang, W.*; Quantification of Bacterial Metabolic Activities in the Gut by D-Amino Acid-based in vivo Labeling. Angew. Chem. Int. Ed., 2020, 59, 12021-12024.

  30. 30. Wu, L; Ding, H; Qu, X; Shi, X; Yang, J; Huang, M; Zhang, J; Zhang, H; Song, J; Zhu, L; Song, Y*; Ma, Y*; Yang, C*; Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability. J. Am. Chem. Soc, 2020, 142, 4800-4806

  31. 31. Ruan, Q; Ruan, W; Lin, X; Wang, Y; Zou, F; Zhou, L; Zhu, Z; Yang, C*; Digital-WGS: Automated, Highly Efficient Whole-genome Sequencing of Single Cells by Digital Microfluidics, Sci. Adv., 2020, 6: eabd6454.

  32. 32. Wang, W; Yang, Q; Du, Y, Zhou, X, Du, X, Wu, Q, Lin, L, Song, Y, Li, F, Yang, C*, Tan, W*. Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables in vivo Imaging of Gut Microbiota. Angew. Chem. Int. Ed., 2020,59, 2628-2633

  33. 33. Lin, L; Wu, Q; Song, J; Du, Y; Gao, J; Song, Y; Wang, W*; Yang, C*, Revealing the in vivo growth and division patterns of mouse gut bacteria, Sci. Adv., 2020, 6, eabb2531.

  34. 34. Huang, M; Yang, J; Wang, T; Song, J; Xia, J; Wu, L; Wang, W; Wu, Q; Zhu, Z; Song, Y*; Yang, C*; Homogeneous, Low-volume, Efficient and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction. Angew. Chem. Int. Ed., 2020, 59, 4800-4805.

  35. 35. Wang, W*; Zhang, N; Du, Y; Gao, J; Li, M; Lin, L; Czajkowsky, D; Li, X*; Yang, C*; Shao, Z. Three-dimensional Quantitative Imaging of Native Microbiota Distribution in the Gut. Angew. Chem. Int. Ed., 2021, 60, 3055-3061.

  36. 36. Wang, W; Lin, L; Du, Y; Song, Y; Peng, X; Chen, X*; Yang, C*. Assessing the Viability of Transplanted Gut Microbiota by Sequential Tagging with D-Amino acid-based Metabolic Probes.Nature Commun., 2019, 10, 1317

  37. 37. Song, Y; Shi, Y; Huang, M; Wang, W; Wang, Y; Cheng, J; Lei, Z; Zhu, Z; Yang, C*; Bioinspired Engineering of Multivalent Aptamer-Functionalized Nanointerface to Enhance Capture and Release of Circulating Tumor Cells. Angew. Chem. Int. Ed., 2019, 58, 2236-2240

  38. 38. Chen, Y; Ke, G*; Ma, Y; Zhu, Z; Liu, M; Liu, Y; Yan, H*; Yang, C*; A Synthetic Light-Driven Substrate Channeling System for Precise Regulation of Enzyme Cascade Activity Based on DNA Origami. J. Am. Chem. Soc.,2018, 28, 8990-8996

  39. 39. Gashaw, M; Abate, M; Song, Y; Zhu, Z; Yan, F; Xu, Y; Wang, X; Li, Q; Yang, C*; Isolation, Detection and Antigen Based Profiling of Circulating Tumor Cells Using a Size Dictated Immunocapture Chip. Angew. Chem. Int. Ed., 2017, 56, 10681-10685

  40. 40. Zhu, Z; Yang, C*; Hydrogel Droplet Microfluidics for High-Throughput Single Molecule/Cell Analysis.Acc. Chem. Res. 2017, 50, 22-31

  41. 41. Ke, G; Liu, M; Jiang, S; Qi, X; Yang, YR; Wootten, S; Zhang, F; Zhu, Z; Liu, Y; Yang, C*; Yan, H*; Directional Regulation of Enzyme Pathways through the Control of Substrate Channeling on a DNA Origami Scaffold, Angew. Chem. Int. Ed., 2016, 55, 7483-7486.

  42. 42. Zhu Z; Guan, Z; Jia S; Lei Z; Lin, S; Zhang, H; Ma, Y; Tian, Z; Yang, C*; Au@Pt Nanoparticle Encapsulated Target-responsive Hydrogel with Volumetric Bar-chart Chip Readout for Quantitative Point-of-care Testing, Angew. Chem. Int. Ed., 2014, 54, 12503-12507.

  43. 43. Tan, J; Ding, L; Ju, H*; Yang, Y; Li, X; Shen, Z; Zhu, Z; Yu, J*; Yang, C*; A Multifunctional Nanomicelle for Real-Time Targeted Imaging and Precise Near-Infrared Therapy of Cancer,Angew. Chem. Int. Ed., 2014, 53, 9544-9549.

  44. 44. Yan, L; Zhu, Z; Zou, Y; Huang, Y; Liu, D; Jia, S; Xu, D; Wu, M; Zhou, Y; Zhou, S; Yang, C*; Target-responsive “Sweet” Hydrogel with Glucometer Readout: an Effective Method for Portable and Quantitative Detection of Non-glucose Targets, J. Am. Chem. Soc., 2013, 135, 3748-3751.

  45. 45. Xiong, X; Liu, H; Zhao, Z; Altman, M; Lopez-Colon, D; Yang, C*; Chang, L; Liu, C; Tan, W*; DNA Aptamer-mediated Cell Targeting, Angew. Chem. Int. Ed., 2013, 52, 1472-1476.

  46. 46. Ke, G; Wang, C; Ge Y; Zheng, N; Zhu Z; Yang, C*, L-DNA Molecular Beacons: A Safe, Stable, and Accurate Intracellular Nano-thermometer for Temperature Sensing in Living Cells,J. Am. Chem. Soc., 2012, 134, 18908-18911.

  47. 47. Wang, K; You, M; Chen, Y; Han, D; Zhu, Z; Huang, J; Williams, K; Yang, C*; Tan, W*; Self-assembly of a Bifunctional DNA Carrier for Drug Delivery, Angew. Chem. Int. Ed., 2011, 50, 6098-6101.

  48. 48. Huang, J; Wu, Y; Chen, Y; Zhu, Z; Yang, X; Yang, C*; Wang, K*; Tan, W*; Pyrene Excimer Probes for Nucleic Acids in Complex Biological Fluids Based on Hybridization Chain Reaction Amplification, Angew. Chem. Int. Ed., 2011, 50, 401-404.

  49. 49. Zhu, Z; Wu, C; Liu, H; Zou, Y; Zhang, X; Kang, H; Yang, C*; Tan, W*; Aptamer-Crosslinked Hydrogel as a Colorimetric Platform for Visual Detection, Angew. Chem. Int. Ed., 2010, 49, 1052-1056.

  50. 50. Yang, C; Wang, L; Wu, Y; Kim, Y; Medley, C. D; Lin, H; Tan, W*; Synthesis and Investigation of Deoxyribonucleic Acid/Locked Nucleic Acid Chimeric Molecular Beacons. Nucleic Acids Res., 2007, 35, 4030-4041.

  51. 51. Yang, C; Martinez, K; Lin, H; Tan, W*; Hybrid Molecular Probe for Nucleic Acid Analysis in Biological Samples, J. Am. Chem. Soc., 2006, 128, 9986-9987

  52. 52. Liu, H; Wang, H; Shi, Z; Wang, H; Yang, C; Silke, S; Tan, W; Lu, Z*; TaqMan probe array for quantitative detection of DNA targets, Nucleic Acids Res., 2006, 34, E4.

  53. 53. Yang, C; Jockusch, S; Vicens, M; Turro, N. J*; Tan, W*; Light-switching Excimer Probes for Rapid Protein Monitoring in Complex Biological Fluids, Proc. Natl. Acad. Sci. U. S. A, 2005, 102, 17278-17283.

  54. 54. Yang, C; Lin, H; Tan, W*; Molecular Assembly of Superquenchers in Signaling Molecular Interactions, J. Am. Chem. Soc., 2005, 127, 12772-12773.

  55. 55. Yang, C; Pinto, M; Schanze, K; Tan, W*; Direct Synthesis of an Oligonucleotide-Poly(Phenylene Ethynylene) Conjugate with a Precise One-to-one Molecular Ratio,Angew. Chem. Int. Ed., 2005, 44, 2572-2576.

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