严晓文

发布日期:2019-09-12     浏览次数:次   

副教授、“南强青年拔尖人才支持计划”特任研究员

办公室:化学楼530室

邮 箱:xwyan@xmu.edu.cn

个人简历:

副教授、特任研究员 (厦门大学化学系 2019.04–至今)

博士后 (加拿大阿尔伯塔大学医学院2013–2019)

理学博士 (厦门大学化学系分析化学专业 2007–2012)

理学学士 (厦门大学化学系化学生物学专业 2003–2007)

获得荣誉:

厦门大学“南强青年拔尖人才支持计划”(2019)

加拿大阿尔伯塔创新未来科技博士后奖(2015)

中国教育部博士研究生学术新人奖(2011)

研究兴趣:
色谱质谱光谱多维分析、功能分子标签、生物分子相互作用、蛋白质组学、金属组学、砷的生物标记与生物效应、新型砷药物研发、生物偶联技术、药物输送

近期主要代表论著:

1.        Yan, X. W.; Le, X. C.*; Zhang, H. Q.* Antibody-bridged beacon for homogeneous detection of small molecules. Anal. Chem. 2018, 90, 9667–9672.

2.        Yan, X. W.; Zhang, H. Q.; Wang, Z. X.; Peng, H. Y.; Tao, J.; Li X. F.; Le, X. C.* Quantitative synthesis of protein-DNA conjugates with 1:1 stoichiometry. Chem. Commun. 2018, 54, 7491–7494.

3.        Yan, X. W.; Li, J. H.; Liu, Q. Q.; Peng, H. Y.; Popowich, A.; Wang, Z. X.; Li, X. F.; Le, X. C.* p-Azidophenylarsenoxide: An arsenical "bait" for the in-situ capture and identification of cellular arsenic-binding proteins. Angew. Chem. Int. Ed. 2016,55, 14051–14056.

4.        Yan, X. W.; Li, Z. X.; Liang, Y.; Yang, L. M.; Zhang, B.; Wang, Q. Q.* A chemical “hub” for absolute quantification of a targeted protein: orthogonal integration of elemental and molecular mass spectrometry. Chem. Commun. 2014, 50, 6578–6581.

5.        Yan, X. W.; Yang, L. M.; Wang, Q. Q.* Detection and quantification of proteins and cells by use of elemental mass spectrometry: progress and challenges. Anal. Bioanal. Chem. 2013, 405, 5663–5670.

6.        Yan, X. W.; Luo, Y. C.; Zhang, Z. B.; Li, Z. X.; Luo, Q.; Yang, L. M.; Zhang, B.; Chen, H. F.; Bai, P. M.; Wang, Q. Q.* Europium-labeled activity-based probe through click chemistry: absolute serine protease quantification using 153Eu isotope dilution ICP/MS. Angew. Chem. Int. Ed. 2012, 51, 3358–3363.

7.        Yan, X. W.; Yang, L. M.; Wang, Q. Q.* Lanthanide-coded protease-specific peptide–nanoparticle probes for label-free multiplex protease assay using element mass spectrometry: a proof-of-concept study. Angew. Chem. Int. Ed. 2011, 50, 5130–5133.

8.        Yan, X. W.; Xu, M.; Yang, L. M.; Wang, Q. Q.* Absolute quantification of intact proteins via 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid-10-maleimido-ethylacetamide-europium labeling and HPLC coupled with species-unspecific isotope dilution ICPMS. Anal. Chem. 2010, 82, 1261–1269.


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