严晓文

个人简历：

副教授、特任研究员 （厦门大学化学系 2019.04–至今）

博士后 （加拿大阿尔伯塔大学医学院2013–2019）

理学博士 （厦门大学化学系分析化学专业 2007–2012）

理学学士 （厦门大学化学系化学生物学专业 2003–2007）

获得荣誉：

厦门大学“南强青年拔尖人才支持计划”（2019）

加拿大阿尔伯塔创新未来科技博士后奖（2015）

中国教育部博士研究生学术新人奖（2011）

研究兴趣：
发展新型靶向共价金属抑制剂用于癌症治疗和生物医学分析；开发位点特异性生物偶联技术，合成多功能抗体-金属药物偶联物用于癌症靶向诊疗；设计高灵敏金属元素标签试剂用于单细胞多参数分析；联合元素质谱和生物质谱技术，开展药物药效和污染物毒性分子机制研究

近期主要代表论著：

1. 1. Yang Zhao, Xinyue Zhao, Lewei Duan, Ruxue Hou, Yuxin Gu, Zhen Liu, Jianbin Chen, Feizhen Wu, Limin Yang, X. Chris Le, Qiuquan Wang, and Xiaowen Yan* Reinvent Aliphatic Arsenicals as Reversible Covalent Warheads toward Targeted Kinase Inhibition and Non-acute Promyelocytic Leukemia Cancer Treatment. J. Med. Chem. 2024, 67, 5458−5472.

2. 2. Xue Liu, Wenjing Ning, Lei Wang, Han Liu, Hongye Zeng, Xiaojing Qin, Yuanzhi Chen, Fentian Chen, Lin Xu, Yang Zhao, Xiaoqing Chen, Jixian Tang, Yunlong Ren, Xiaowen Yan*, Wenxin Luo*, Ningshao Xia* Engineering heavy chain antibody-drug conjugates against solid tumors for a one-shot kill. Cancer Communications 2024, DOI: 10.1002/cac2.12616.

3. 3. Xiaokang Guan, Qiao Lu, Shuxian Liu, Xiaowen Yan* Post-ionization mass spectrometry imaging: Past, present, and future. Mass Spectrom. Rev. 2024, DOI:10.1002/mas.21918.

4. 4. Ruxue Hou, Yuxin Gu, Yang Zhao, Xinyue Zhao, Limin Yang, Xiaowen Yan,* and Qiuquan Wang Covalent Targeting Drug Mediated Specific Lanthanide Tagging Towards In Situ Bruton's Tyrosine Kinase Quantification Using ICP-MS. Atom. Spectrosc. 2024, 45(2), 74–82.

5. 5. Zhengxian Lv, Xinli Yan, Zhen Liu, Shi Chen, Xiaowen Yan,* Limin Yang, and Qiuquan Wang* A CH4-Driven Ion Cloud-Stretched Approach Enables ICP-qMS for Multiplex Single-Cell Analysis. Chem. Eur. J. 2024, e202402289.

6. 6. Jianyu Hu, Xiaowen Yan,* X. Chris Le* Label‑free detection of biomolecules using inductively coupled plasma mass spectrometry (ICP‑MS). Anal. Bioanal. Chem. 2024, 416, 2625–2640.

7. 7. Lei Wang, Li Yi, Huamin Li, Limin Yang, Xiaowen Yan,* Qiuquan Wang* Synthesis and Single-cell Analysis Application of Antibody-Element-Tag Based on Peptide Affinity-mediated Site-specific Labeling Strategy. Chinese J. Anal. Chem. 2024, 52, 1496-1507

8. 8. Xiaokang Guan, Qiao Lu, Xiangxu Zhao, Xiaowen Yan,* and Renato Zenobi* Spatio-Temporal Analysis of Anesthetics in Mice by Solid-Phase Microextraction: Dielectric Barrier Discharge Ionization Mass Spectrometry. Anal. Chem. 2023, 95, 12470–12477.

9. 9. Xin Jin, Limin Yang,* Xiaowen Yan,* Qiuquan Wang* Screening platform based on inductively coupled plasma mass spectrometry for β‑site amyloid protein cleaving enzyme 1 (BACE1) inhibitors. ACS Chem. Neurosci. 2021, 12, 1093-1099.

10. 10. Xiaowen Yan, X. Chris Le* Fluorescence imaging of Cu(I) in endoplasmic reticulum of live cells and tissue. Sci. China Chem. 2019, 62, 887-888.