方华攀

个人简历：

教育经历:

2010-2014  湖北大学，学士

2014-2019  中国科学院长春应化所，博士（导师：田华雨教授，陈学思院士）

工作经历:

2020-2022  苏州大学，博士后（合作导师：刘庄教授）

2022.12-   厦门大学化学化工学院，副教授

目前兼职：The Innovation、VIEW以及Brain-X等青年编委

获得荣誉:

福建省高层次人才（2023）

厦门大学“南强青年拔尖人才支持计划”（2022）

中国科学院院长优秀奖（2019）

研究兴趣：
生物医用高分子；生物材料；高分子核酸/药物载体；肿瘤免疫治疗；蛋白/多肽递送

近期主要代表论著：

1. 1. Huapan Fang^#, Zhaopei Guo^#, Jie Chen, Lin Lin, Yingying Hu, Yanhui Li*, Huayu Tian*, Xuesi Chen. Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo. Nat. Commun. 2021, 12, 6742.

2. 2. Huapan Fang, Zhaopei Guo, Lin Lin, Jie Chen, Pingjie Sun, Jiayan Wu, Caina Xu, Huayu Tian*, Xuesi Chen*. Molecular strings significantly improved the gene transfection efficiency of polycations. J. Am. Chem. Soc. 2018, 140, 11992-12000.

3. 3. Huapan Fang, Linfu Chen, Zheng Deng, Yunxuan Gao, Yang Yang, Qian Chen*, Zhuang Liu*. In situ polymerization of zwitterions on therapeutic proteins to enable their effective oral delivery. ACS Nano 2023, 17, 1128-1143.

4. 4. Huapan Fang, Yicheng Wu, Linfu Chen, Zhiqin Cao, Zheng Deng, Rui Zhao, Lin Zhang, Yang Yang,* Zhuang Liu,* and Qian Chen*. Regulating the obesity-related tumor microenvironment to improve cancer immunotherapy. ACS Nano 2023, 17, 4748-4763.

5. 5. Mingzhuang Li, Yingyao Wang, Lin Zhang, Qin Liu, Feizhou Jiang, Wenjie Hou, Yudong Wang*, Huapan Fang*, Yueming Zhang*. Cancer cell membrane-enveloped dexamethasone normalizes the tumor microenvironment and enhances gynecologic cancer chemotherapy. ACS Nano 2023, 17, 16703-16714.

6. 6. Shengting Dong, Huapan Fang*, Junjie Zhu, Zhiqiang Wu, Yi Liu, Jiafei Zhu, Benting Ma, Qian Chen, Yang Yang*. Inhalable siRNA targeting IL-11 nanoparticles significantly inhibit bleomycin-induced pulmonary fibrosis. ACS Nano 2025, 19, 2742-2758.

7. 7. Qiannan Cao, Huapan Fang*, Huayu Tian*. mRNA vaccines contribute to innate and adaptive immunity to enhance immune response In Vivo. Biomaterials 2024, 310, 122628.

8. 8. Huapan Fang^#, *, Lin Zhang^#, Yicheng Wu, Linfu Chen, Zheng Deng, Zixuan Zheng, Yudong Wang, Yang Yang, Qian Chen*. Carrier-free multifunctional nanomedicine for enhanced hyperthermic intraperitoneal chemotherapy against abdominal pelvic tumors. Chem. Eng. J. 2024, 498, 155781.

9. 9. Mingxia Jiang, Huapan Fang*, Huayu Tian*. Latest advancements and trends in biomedical polymers for disease prevention, diagnosis, treatment, and clinical application. J. Controlled Release 2025, 380, 138-174.

10. 10. Mingxia Jiang, Huapan Fang*, Huayu Tian*. Metabolism of cancer cells and immune cells in the initiation, progression, and metastasis of cancer. Theranostics 2025, 15, 155-188.

11. 11. Xiaoya Guo, Zhiyu Yang, Huapan Fang*, Danhua Zhou, Xuan Pang, Huayu Tian*, Xuesi Chen. Modulating the oxidation degree of linear polyethyleneimine for preparation of highly efficient and low-cytotoxicity degradable gene delivery carriers. Chinese J. Poly. Sci. 2024, 1, 1-11.

12. 12. Zhiyu Yang, Xiaoya Guo, Meng Meng, Tong Li, Huapan Fang*, Zhaohui Tang, Huayu Tian*, Xuesi Chen. A single magnetic nanoplatform-mediated combination therapy of immune checkpoint silencing and magnetic hyperthermia for enhanced anti-cancer immunity. Nano Res. 2023, 16, 11206-11215.

13. 13. Siting Zhang, Huapan Fang*, Huayu Tian*. Recent advances in degradable biomedical polymers for prevention, diagnosis and treatment of diseases. Biomacromolecules 2024, 25, 7015-7057.

14. 14. Huilin Yuan, Mingxia Jiang, Huapan Fang*, Huayu Tian*. Recent advances in poly(amino acids), polypeptides, and their derivatives in drug delivery. Nanoscale, 2025, 17, 3549-3584.

15. 15. Dayang Xie, Qiannan Cao, Huapan Fang*, Yanhui Li*, Huayu Tian*, Applications and challenges of biomedical polymer materials in pulmonary diseases. Chin. Chem. Lett. 2025, 111032.

16. 16. Huapan Fang*, Qian Chen. Applications and challenges of biomaterial mediated mRNA delivery. Explor Target Antitumor Ther. 2022, 3, 428-444.

17. 17. Huapan Fang, Jie Chen, Lin Lin, Feng Liu, Huayu Tian*, Xuesi Chen. A strategy of killing three birds with one stone for cancer therapy through regulating the tumor microenvironment by H₂O₂-responsive Gene Delivery System. ACS Appl. Mater. Interfaces 2019, 11, 47785-47797.

18. 18. Huapan Fang^#, Yuanji Feng^#, Jie Chen, Huayu Tian*, Xuesi Chen. Constructing efficient polycationic gene carriers through regulating the physicochemical properties. Mater. Today Chem. 2019, 11, 269-282.

19. 19. Huapan Fang^#, Lin Lin^#, Jie Chen, Jiayan Wu, Huayu Tian*, Xuesi Chen. Zinc ion coordination significantly improved the transfection efficiency of low molecular weight polyethylenimine. Biomater. Sci., 2019, 7, 1716-1728.

20. 20. Jie Chen^#, Huapan Fang^#, Yingying Hu, Jiayan Wu, Sijia Zhang, Yuanji Feng, Lin Lin, Huayu Tian*, Xuesi Chen. Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy. Bioact. Mater. 2022, 7, 167-180.