方华攀

个人简历：

教育经历:

2014-2019  中国科学院长春应化所，博士（导师：田华雨教授，陈学思院士）

工作经历:

2020-2022  苏州大学，博士后（合作导师：刘庄教授）

2022.12-   厦门大学化学化工学院，副教授

目前兼职：

The Innovation、Chinese Chemical Letters、Exploration、VIEW以及Brain-X等青年编委, Scientific Reports 编委

获得荣誉:

福建省高层次人才（2023）

厦门大学“南强青年拔尖人才支持计划”（2022）

中国科学院院长优秀奖（2019）

研究兴趣：
生物医用高分子；生物材料；高分子核酸/药物载体；肿瘤免疫治疗；蛋白/多肽递送

近期主要代表论著：

1. 1. Huapan Fang^#, Zhaopei Guo^#, Jie Chen, Lin Lin, Yingying Hu, Yanhui Li*, Huayu Tian*, Xuesi Chen. Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivo. Nat. Commun. 2021, 12, 6742.

2. 2. Shengting Dong, Huapan Fang*, Junjie Zhu, Zhiqiang Wu, Yi Liu, Jiafei Zhu, Benting Ma, Qian Chen, Yang Yang*. Inhalable siRNA targeting IL-11 nanoparticles significantly inhibit bleomycin-induced pulmonary fibrosis. ACS Nano 2025, 19, 2742-2758.

3. 3. Hongqian Liu, Qiannan Cao, Yingli Yao, Wenming Zheng, Dayang Xie, Mingxia Jiang, Pijun Su, Siting Zhang, Huilin Yuan, Huapan Fang*, Huayu Tian*. Polyoxazoline-Based Gene Delivery System Mediated Tumor Vascular Normalization and Extracellular Matrix Degradation to Inhibit Cancer Growth, Recurrence, and Metastasis. Adv. Funct. Mater. 2025, 2502657.

4. 4. Mingzhuang Li, Yingyao Wang, Lin Zhang, Qin Liu, Feizhou Jiang, Wenjie Hou, Yudong Wang*, Huapan Fang*, Yueming Zhang*. Cancer cell membrane-enveloped dexamethasone normalizes the tumor microenvironment and enhances gynecologic cancer chemotherapy. ACS Nano 2023, 17, 16703-16714.

5. 5. Qiannan Cao, Huapan Fang*, Huayu Tian*. mRNA vaccines contribute to innate and adaptive immunity to enhance immune response In Vivo. Biomaterials 2024, 310, 122628.

6. 6. Mengtian He, Dayang Xie, Qiannan Cao, Mingxia Jiang, Hongqian Liu, Yingli Yao, Wenming Zheng, Huilin Yuan, Pijun Su, Siting Zhang, Yuxuan He, Shuting Zeng, Yaqing Zeng, Huapan Fang*, Hong Wu*, Huayu Tian, Polymer-based gene-drug co-delivery system effectively inhibits pathologic retinal neovascularization through dual anti-inflammatory and anti-neovascular actions, Biomaterials, 2025, 326, 123680.

7. 7. Huapan Fang, Zhaopei Guo, Lin Lin, Jie Chen, Pingjie Sun, Jiayan Wu, Caina Xu, Huayu Tian*, Xuesi Chen*. Molecular strings significantly improved the gene transfection efficiency of polycations. J. Am. Chem. Soc. 2018, 140, 11992-12000.

8. 8. Huapan Fang, Linfu Chen, Zheng Deng, Yunxuan Gao, Yang Yang, Qian Chen*, Zhuang Liu*. In situ polymerization of zwitterions on therapeutic proteins to enable their effective oral delivery. ACS Nano 2023, 17, 1128-1143.

9. 9. Huapan Fang, Yicheng Wu, Linfu Chen, Zhiqin Cao, Zheng Deng, Rui Zhao, Lin Zhang, Yang Yang,* Zhuang Liu,* and Qian Chen*. Regulating the obesity-related tumor microenvironment to improve cancer immunotherapy. ACS Nano 2023, 17, 4748-4763.

10. 10. Huapan Fang^#, *, Lin Zhang^#, Yicheng Wu, Linfu Chen, Zheng Deng, Zixuan Zheng, Yudong Wang, Yang Yang, Qian Chen*. Carrier-free multifunctional nanomedicine for enhanced hyperthermic intraperitoneal chemotherapy against abdominal pelvic tumors. Chem. Eng. J. 2024, 498, 155781.

11. 11. Mingxia Jiang, Huapan Fang*, Huayu Tian*. Latest advancements and trends in biomedical polymers for disease prevention, diagnosis, treatment, and clinical application. J. Controlled Release 2025, 380, 138-174.

12. 12. Mingxia Jiang, Huapan Fang*, Huayu Tian*. Metabolism of cancer cells and immune cells in the initiation, progression, and metastasis of cancer. Theranostics 2025, 15, 155-188.

13. 13. Xiaoya Guo, Zhiyu Yang, Huapan Fang*, Danhua Zhou, Xuan Pang, Huayu Tian*, Xuesi Chen. Modulating the oxidation degree of linear polyethyleneimine for preparation of highly efficient and low-cytotoxicity degradable gene delivery carriers. Chinese J. Poly. Sci. 2024, 1, 1-11.

14. 14. Zhiyu Yang, Xiaoya Guo, Meng Meng, Tong Li, Huapan Fang*, Zhaohui Tang, Huayu Tian*, Xuesi Chen. A single magnetic nanoplatform-mediated combination therapy of immune checkpoint silencing and magnetic hyperthermia for enhanced anti-cancer immunity. Nano Res. 2023, 16, 11206-11215.

15. 15. Siting Zhang, Huapan Fang*, Huayu Tian*. Recent advances in degradable biomedical polymers for prevention, diagnosis and treatment of diseases. Biomacromolecules 2024, 25, 7015-7057.

16. 16. Huilin Yuan, Mingxia Jiang, Huapan Fang*, Huayu Tian*. Recent advances in poly(amino acids), polypeptides, and their derivatives in drug delivery. Nanoscale, 2025, 17, 3549-3584.

17. 17. Dayang Xie, Qiannan Cao, Huapan Fang*, Yanhui Li*, Huayu Tian*, Applications and challenges of biomedical polymer materials in pulmonary diseases. Chin. Chem. Lett. 2025, 111032.

18. 18. Qiannan Cao, Yu Liang, Weiyi Xia, Anna Guo, Mingxia Jiang, Lai Yang, Qiaoyan Dong, Wenming Zheng, Yingli Yao, Siting Zhang, Huilin Yuan, Pijun Su, Rongmei Zhou, Songyu Xu, Bo Chen*, Jing Yao*, Huapan Fang*, Huayu Tian, Polycation-based miRNA delivery system for choroidal neovascularization treatment, Chin. Chem. Lett. 2025, 112031.

19. 19. Anna Guo, Qiannan Cao, Huapan Fang*, Huayu Tian*, Recent advances and challenges of injectable hydrogels in drug delivery, J. Controlled Release 2025, 385, 114021.

20. 20. Yingli Yao, Qiannan Cao, Huapan Fang*, Huayu Tian, Application of nanomaterials in the diagnosis and treatment of retinal diseases, Small 2025, 21, 2503070.

21. 21. Wenming Zheng, Mingxia Jiang, Nuo Dong, Huapan Fang*, Huayu Tian*, Xuesi Chen, Opportunities and challenges of biomaterials in brain disease, Adv. Healthcare Mater. 2025, 14, 2500746.