林泓域/Hongyu Lin
教授、博士生导师
办公室：卢嘉锡楼542室
电子邮箱：hylin007@xmu.edu.cn
个人简历：
学士（南京大学化学化工学院，2003-2007）
博士（美国Brandeis University化学系，2007-2012）
博士后（美国Cornell University化学与化学生物学系，2013-2015）
副教授（厦门大学化学化工学院化学生物学系，2016-2024）
教授（厦门大学化学化工学院化学生物学系，2024-）
福建省化学生物学重点实验室和谱学分析与仪器教育部重点实验室固定成员。主持国家自然科学基金重大研究计划培育项目、面上项目、福建省自然科学基金杰出青年基金项目等，授权中国发明专利3项。
研究兴趣：
磁共振造影剂；19F磁共振探针；19F代谢标记；分子探针；肿瘤诊疗
近期主要代表论著：
# co-first authors, * corresponding authors
1. Jiang, Y.; Wang, J.; Tan, C.; Lin, L.; Li, Y.; Lin, H.*; Gao, J.* Nuclear Spin Relaxation Modulation of Fluorinated Deep Eutectic Solvents for Radiofrequency Information Encoding and Display. Adv. Mater. 2026, 38， e73987.
2. Zheng, L.#; Peng, Q.#; Sun, H.; Deng, J.; Jiang, J.; Xiong, Y.; Chen, L.; Cui, X.; Lin, H.*; Chen, Z.*; Wang, X.*; Gao, J.* SABRE Hyperpolarized Multichannel 19F NMR for Sensitive Detection of Multiple Disease Marker Enzymes on a Benchtop NMR. Angew. Chem. Int. Ed.2026, 65, e17348.
3. Jiang, Y.; Fan, Y.; Chen, L.; Lin, H.*; Gao, J.* Super-multiplexed imaging and coding in the range of radio frequency. Nat. Commun. 2025, 16, 2567.
4. Jiang, Y.; Chen, L.; Wang, J.; Lin, H.*; Gao, J.* Small Fluorinated Aromatic Molecule-Based Radiofrequency Identification Tags Enabled by Stepwise Tuning of Nuclear Shielding. Angew. Chem. Int. Ed.2025, 64, e20250684.
5. Li, L.#; Li, A.#; Wang, J.; Shao, J.; Zhou, J.; Peng, Z.; Lin, H.*; Gao, J.* Visualizing enterohepatic circulation in vivo by sensitive 19F MRI with a fluorinated ferrous chelate-based small molecule probe. Biomaterials 2025, 317, 123073
6. Chen, L.; Jiang, Y.; Xiong, N.; Fan, Y.; Lin, H.*; Gao, J.* Sensitive Multichannel 19F Magnetic Resonance Imaging Enabled by Paramagnetic Fluorinated Ionic Liquid-Based Probes. ACS Nano2025, 15, 9061.
7. Chen, D.; Lin, Y.; Fan, Y.; Li, L.; Tan, C.; Wang, J.; Lin, H.*; Gao, J.* Glycan Metabolic Fluorine Labeling for In Vivo Visualization of Tumor Cells and In Situ Assessment of Glycosylation Variations. Angew. Chem. Int. Ed.2023, 62, e202313753.
8. Chen, D.#; Guo, J.#; Li, A.; Sun, C.; Lin, H.; Lin, H.*; Yang, C.*; Wang, W.*; Gao, J.* Metabolic Fluorine Labeling and Hotspot Imaging of Dynamic Gut Microbiota in Mice. Sci. Adv. 2023, 9, eabg6808.
9. Tang, X.#; Li, A.#; Zuo, C.; Liu, X.; Luo, X.; Chen, L.; Li, L.; Lin, H.*; Gao, J.* Water-Soluble Chemically Precise Fluorinated Molecular Clusters for Interference-Free Multiplex 19F MRI in Living Mice. ACS Nano 2023, 17, 5014.
10. Luo, X.; Kang, B.; Chi, X.; Xiong, H.; Chen, D.; Fan, Y.; Li, L.; Chen, L.; Li, A.; Gao, J.; Lin, H.* 19F Barcoding Enables Multiplex Detection of Biomarkers Associated with Organ Injury and Cancer Angew. Chem. Int. Ed.2022, 61, e202211189.
11. Yang, Z.#; Sun, C.#; Lin, Y.; Lin, H.; Gao, J.; Lin, H.* Sequence-Controlled Heterolayered Lanthanide-Complex Dendritic Architectures Constructed from Modular Ln-DOTA Derivatives. Cell Rep. Phys. Sci. 2022, 3, 100950.
12. Liu, K.; Kang, B.; Luo, X.; Yang, Z.; Sun, C.; Li, A.; Fan, Y.; Chen, X.; Gao, J.*; Lin, H.* Redox-Activated Contrast-Enhanced T1-Weighted Imaging Visualizes Glutathione-Mediated Biotransformation Dynamics in the Liver. ACS Nano2021, 15, 11831-11841.
