张瑷珲

个人简历：

2024－今　　副研究员　　厦门大学化学化工学院

2019－2022　博士后　　厦门大学化学化工学院

2016－2019　博士　　　厦门大学化学化工学院

2012－2015　硕士　　　南京工业大学生物与制药工程学院

获得荣誉：

(1) 2021年，用于1,3-丙二醇生产的丁酸梭菌发酵代谢轮廓分析和适应性进化研究，福建省教育厅，福建省优秀博士论文。

(2) 2020年，1,3-丙二醇反复分批发酵过程代谢轮廓分析，福建省教育厅，第十四届福建省自然科学优秀学术论文，三等奖。

(3) 2023年，第七届全国化学工程与生物化工年会，优秀青年报告奖。

(4) 2023年，生物工程学科发展战略研讨会，优秀报告奖。

(5) 2023年，第六届生物化学青年学者论坛，优秀报告奖。

研究兴趣：

合成生物学、代谢工程、酶工程、发酵工程。

重点研究课题为：AI赋能生物制造、单分子尺度酶催化过程研究、工业微生物细胞工厂构建。

承担课题：

(1) 人力资源和社会保障部，国家博士后创新人才支持计划“博新计划”，已结题，400人/年。

(2) 国家自然科学基金青年项目，在研，（2024.01-2026.12）。

近期主要代表论著：

1. (1) Zhang Aihui^#, Zhuang Xiaoyan^#, Liu Jia^#, Huang Jiacheng^#, Lin Luchun, Tang Yongxiang, Zhao Shiqiang, Li Ruihao, Wang Binju*, Fang Baishan*, Hong Wenjing*. Catalytic cycle of formate dehydrogenase captured by single-molecule conductance. Nature Catalysis, 2023, 6: 266-275. (ESI高被引)

2. (2) Huang Jiacheng, Li Chade-Deng, Zhao Haodong, Yu Meng, Zhang Aihui*, Fang Baishan*. Artificial intelligence system for enhanced automated 1,3-propanediol green biosynthesis. Green Chemistry, 2023, 25: 9175-9186. (共同通讯)

3. (3) Wang Kaifeng, Zhao Wenyang, Lin Lu, Wang Tianjing, Wei Ping, Ledesma-Amaro Rodrigo, Zhang Aihui*, Ji Xiaojun*. A robust soft sensor based on artificial neural network to monitor microbial lipid fermentation process by Yarrowia lipolytica. Biotechnology and Bioengineering, 2023, 120: 1015-1025. (共同通讯)

4. (4) Zhang Aihui^#, Zhu Kaiyi^#, Zhuang Xiaoyan, Liao Langxing, Huang Shiyang, Yao Chuanyi*, Fang Baishan*. A robust soft sensor to monitor 1,3-propanediol fermentation process by Clostridium butyricum based on artificial neural network. Biotechnology and Bioengineering, 2020, 117(11): 3345-3355.

5. (5) Zhuang Xiaoyan^#, Zhang Aihui^#, Qiu Siyao, Tang Chun, Zhao Shiqiang, Li Hongchun, Zhang Yonghui, Wang yali, Wang Binju, Fang Baishan*, Hong Wenjing*. Coenzyme coupling boosts charge transport through single bioactive enzyme junctions. iScience, 2020, 23(‏4): 101001.

6. (6) Zhang Aihui, Zhuang Xiaoyan, Chen Kainan, Huang Shiyang, Xu Chaozhen, Fang Baishan*. Adaptive evolution of Clostridium butyricum and scale-up for high-concentration 1,3-propanediol production. AIChE Journal, 2019, 65(1): 32-39.

7. (7) Zhang Aihui, Huang Shiyang, Zhuang Xiaoyan, Wang Ke, Yao Chuanyi*, Fang Baishan*. A novel kinetic model to describe 1,3-propanediol production fermentation by Clostridium butyricum. AIChE Journal, 2019, 65(6): e16587.

8. (8) Zhang Aihui, Liu Haolin, Huang Shiyang, Fu Yousi, Fang Baishan*. Metabolic profiles analysis of 1,3-propanediol production process by Clostridium butyricum through repeated batch fermentation coupled with activated carbon adsorption. Biotechnology and Bioengineering, 2018, 115: 684-693.

9. (9) Chen Junhong, Zhuang Xiaoyan, Zheng Jiyang, Yang Ruofan, Wu Fei, Zhang Aihui*, Fang Baishan*. Aptamer-based cell-free detection system to detect target protein. Synthetic and Systems Biotechnology, 2021, 6: 209-215. (综述，共同通讯)

10. (10) Bi Ruomeng, Ou Meihao, Zhou Siru, Geng Shichen, Zheng Yixian, Chen Junhong, Mo Ruijie, Li Yuan, Xiao Gezhi, Chen Xingyu, Zhai Shiyi, Zhang Aihui*, Fang Baishan*. Degradation strategies of pesticide residue: From chemicals to synthetic biology Synthetic and Systems Biotechnology, 2023, 6: 209-215. (共同通讯)