学术讲座
报告题目：Chiral Ligands Providing Attractive Noncovalent Interactions
报告时间：2025-07-23 09:00
报告人： Prof. Sukwon Hong（洪錫湲）
韩国光州科学技术院
报告地点：卢嘉锡楼202报告厅
报告摘要：
The application of attractive noncovalent interactions has emerged as an elegant strategy in the asymmetric catalysis. Although conventional asymmetric catalysis utilizes repulsive steric interactions to destabilize transition states of minor enantiomers, attractive noncovalent interactions such as ion-pairing, hydrogen bonding, and aromatic interactions could provide an alternative ‘enzyme-like’ pathway to stabilize the transition states of major enantiomers. In our laboratory, a series of hydrogen-bond functionalized salen-transition metal catalysts were developed to facilitate bimetallic or bifunctional activation of both reaction partners. Cation‐binding salen nickel catalysts were developed for the enantioselective alkynylation of trifluoromethyl ketones in high yield (up to 99%) and high enantioselectivity (up to 97% ee). Palladium complexes with chiral pyridine-dihydroisoquinoline (PyDHIQ) ligands enabled highly enantioselective conjugate addition reactions of arylboronic acids to 2-substituted chromones and β-methyl α,β-unsaturated δ-lactams. The effect of π-interactions on the high enantioselectivity was elucidated by DFT calculations and noncovalent interaction analysis. Recently, novel chiral N-Heterocyclic Carbene (NHC)-palladium complexes featuring an anagostic C-H···Pd interaction were successfully applied to the enantioselective desymmetric C-N cross-coupling reactions.
报告人简介：
Sukwon Hong is a Professor of Chemistry in the Department of Chemistry at the Gwangju Institute of Science and Technology (GIST), Korea. He received his B.S. (1995) and M.S. (1997) degrees from Seoul National University, where he conducted research on the total synthesis of alkaloids under the guidance of Prof. Eun Lee. He earned his Ph.D. from Northwestern University in 2003, working with Prof. Tobin Marks on organolanthanide-catalyzed hydroamination reactions. He then carried out postdoctoral research with Prof. Dale Boger at The Scripps Research Institute, focusing on α-helix mimetic small molecule combinatorial library targeting protein-protein interactions. Prof. Hong began his independent academic career in 2005 as an Assistant Professor at the University of Florida (USA). In 2012, he joined GIST, where he was promoted to full professor. His research interests lie in the development of transition-metal-catalysts for organic synthesis. He is particularly interested in designing new types of transition metal catalysts that can offer highly efficient synthetic routes to functional organic materials, and applying them in synthesizing chiral building blocks, catalytic CO2 conversion, olefin metathesis, and constructing organic electronic devices.
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