仪器讲座
报告题目：Ultra-high resolution and ultra-selective NMR Spectroscopy
报告时间：2026-04-10 10:00
报告人： Prof. Ralph W. Adams
University of Manchester, UK
报告地点：卢嘉锡楼202报告厅
转播地点：翔安校区能源材料大楼3号楼会议室2
报告摘要：
NMR spectroscopy excels at distinguishing chemically distinct sites to reveal molecular structure and dynamics, but spectral overlap—exacerbated by homonuclear scalar (J) coupling in ¹H NMR—limits its utility for complex molecules. Conventional 2D NMR alleviates overlap by adding dimensionality and revealing structural correlations, yet it often includes redundant data and requires long acquisition times. Two complementary strategies resolve ¹H NMR overlap:
1. Pure shift NMR: Suppresses homonuclear J coupling to collapse multiplets into single peaks, yielding ultrahigh-resolution spectra. This approach extends to multidimensional experiments (e.g., HSQC, DOSY) for clearer correlation patterns.
2. Ultra-selective excitation: Uses the GEMSTONE pulse sequence to isolate specific ¹H signals from overlapping multiplets in a single scan, expanding selective 1D experiments (e.g., NOESY, TOCSY, ROESY, and COSY) to reveal spatial and connectivity details.
Combining these two approaches, an ultra-selective ultra-high resolution experiment can be acquired that overcomes signal overlap in complex mixtures. By simplifying spectral appearance while enabling precise targeting of individual signals, these methods provide fast, information-rich alternatives to conventional multidimensional experiments and extend NMR analysis to increasingly complex chemical systems.
报告人简介：
Alph Adams received his MChem in Chemistry from the University of York in 2005, with a final-year placement at GSK R&D working on isomer separation for Lapatinib synthesis. He completed his BBSRC-funded PhD in MRI hyperpolarisation at York in 2009, then applied his developed SABRE hyperpolarisation method at Yorkshire Forward and Bruker for MRI and high-field NMR studies. In late 2010, he joined the University of Manchester as an EPSRC postdoctoral researcher on MAD spectroscopy, later acting as Co-Investigator on an EPSRC grant for pure shift NMR development.
He is currently a Senior Research Fellow in NMR Spectroscopy, managing departmental NMR facilities and services, and leading research on pulse sequence design and novel applications of hyperpolarised spin states.
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